Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes
文献类型：期刊论文
| 作者 | Duan, Hongliang; Ning, Mengmeng ; Zou, Qingan; Ye, Yangliang; Feng, Ying; Zhang, Lina; Leng, Ying; Shen, Jianhua
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| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2015-04-23 |
| 卷号 | 58期号:8页码:3315-3328 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/jm500829b |
| 文献子类 | Article |
| 英文摘要 | Activation of TGR5 stimulates intestinal glucagon-like peptide-1 (GLP-1) release, but activation of the receptors in gallbladder and heart has been shown to cause severe on-target side effects. A series of low-absorbed TGR5 agonists was prepared by modifying compound |
| WOS关键词 | BILE-ACID RECEPTOR ; ENTEROENDOCRINE CELL-LINE ; PEPTIDE-1 SECRETION ; HIGHLY POTENT ; DERIVATIVES ; ABSORPTION ; INHIBITOR ; DRUGS ; MICE |
| 资助项目 | "National Science and Technology Major Project-Key New Drug Creation and Manufacturing program, China"[2012ZX09103101-049] ; National Nature Science Foundation of China[81202571] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000353602200004 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276567]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 |
| 通讯作者 | Leng, Ying |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Hongliang,Ning, Mengmeng,Zou, Qingan,et al. Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes[J]. JOURNAL OF MEDICINAL CHEMISTRY,2015,58(8):3315-3328. |
| APA | Duan, Hongliang.,Ning, Mengmeng.,Zou, Qingan.,Ye, Yangliang.,Feng, Ying.,...&Shen, Jianhua.(2015).Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes.JOURNAL OF MEDICINAL CHEMISTRY,58(8),3315-3328. |
| MLA | Duan, Hongliang,et al."Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes".JOURNAL OF MEDICINAL CHEMISTRY 58.8(2015):3315-3328. |
入库方式： OAI收割
来源：上海药物研究所
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