Chemical Constituents from the Heartwood of Haematoxylon campechianum as Protein Tyrosine Kinase Inhibitors
文献类型：期刊论文
| 作者 | Lin, Li-Gen1,2; Xie, Hua1 ; Wang, Yi-Tao2; Ding, Jian1; Ye, Yang1
|
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2014-05 |
| 卷号 | 11期号:5页码:776-783 |
| 关键词 | Haematoxylon campechianum Protein tyrosine kinases (PTKs) Epihematoxylol B Homoisoflavonoids Hematoxylol B 10-O-methyl- Kinase insert domain receptor (KDR) |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.201300183 |
| 文献子类 | Article |
| 英文摘要 | In a previous study, we showed that a series of homoisoflavonoids from the stems of Haematoxylon campechianum possess potent protein tyrosine kinase inhibitory activity. In a further chemical investigation of the heartwood of H. campechianum, three new homoisoflavonoids, epihematoxylol B (2), 10-O-methylhematoxylol B (3), and 10-O-methylepihematoxylol B (4), were isolated and identified, together with 15 known compounds, including three homoisoflavonoids, three flavonoids, six lignans, and three unsaturated fatty acids. The structures of the new compounds were established on the basis of 1D- and 2D-NMR and other spectroscopic analyses. |
| WOS关键词 | FLAVONOIDS ; LIGNANS ; DERIVATIVES ; CHINENSIS ; GROWTH ; SAPPAN |
| 资助项目 | National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2009ZX09103-419] ; National Natural Sciences Funds for Distinguished Young Scholar[30925043] ; Macao Science and Technology Development Fund[074/2012/A3] ; University of Macau[SRG2013-00038-ICMS-QRCM] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000336376200009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277092]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Lin, Li-Gen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Li-Gen,Xie, Hua,Wang, Yi-Tao,et al. Chemical Constituents from the Heartwood of Haematoxylon campechianum as Protein Tyrosine Kinase Inhibitors[J]. CHEMISTRY & BIODIVERSITY,2014,11(5):776-783. |
| APA | Lin, Li-Gen,Xie, Hua,Wang, Yi-Tao,Ding, Jian,&Ye, Yang.(2014).Chemical Constituents from the Heartwood of Haematoxylon campechianum as Protein Tyrosine Kinase Inhibitors.CHEMISTRY & BIODIVERSITY,11(5),776-783. |
| MLA | Lin, Li-Gen,et al."Chemical Constituents from the Heartwood of Haematoxylon campechianum as Protein Tyrosine Kinase Inhibitors".CHEMISTRY & BIODIVERSITY 11.5(2014):776-783. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。