Novel 2,4-Diarylanninopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities
文献类型：期刊论文
| 作者 | Liu, Zhiqing1,2; Ai, Jing3 ; Peng, Xia3; Song, Zilan1,2; Wu, Kui4; Zhang, Jing1,2; Yao, Qizheng4; Chen, Yi3; Ji, Yinchun3; Yang, Yanhong3
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| 刊名 | ACS MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2014-04 |
| 卷号 | 5期号:4页码:304-308 |
| 关键词 | C1-Substituted-N3-benzazepine c-Met/ALK dual inhibitor structure repurposing 2,4-diarylaminopyrimidine analogues |
| ISSN号 | 1948-5875 |
| DOI | 10.1021/ml400373j |
| 文献子类 | Article |
| 英文摘要 | By repurposing a typical dopamine D-1/D-5 receptor agonist motif, C1-substituted-N3-benzazepine or benzazecine, into the classical RTK inhibitor 2,4-diaminopyrimidine skeleton, a series of new 2,4-diarylaminopyrimidine analogues (DAAPalogues) were developed. Compounds 7 and 8a were identified possessing high potency against both c-Met and ALK kinases. Compound 8a displayed appreciable antitumor efficacy at the dose of 1 mg/kg in the ALK-driven BF3/EML4-ALK xenograft mice model. |
| WOS关键词 | ANAPLASTIC LYMPHOMA KINASE ; CELL LUNG-CANCER ; MET INHIBITORS ; EFFICACIOUS INHIBITOR ; RECEPTOR LIGANDS ; ALK INHIBITORS ; DISCOVERY ; IDENTIFICATION ; PF-2341066 ; THERAPY |
| 资助项目 | Chinese NSF[81125021] ; Chinese NSF[81373277] ; Chinese NSF[81102461] ; Chinese NSF[91229205] ; National Science & Technology Major Project on 'Key New Drug Creation and Manufacturing Program' China[2012ZX09103-101-035] ; National Science & Technology Major Project on 'Key New Drug Creation and Manufacturing Program' China[2012ZX09301001-007] ; National Science & Technology Major Project on 'Key New Drug Creation and Manufacturing Program' China[2012ZX09301001-001] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000334571400006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277133]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Geng, Meiyu |
| 作者单位 | 1.Chinese Acad Sci, SIMM, SOMCL, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China; 4.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhiqing,Ai, Jing,Peng, Xia,et al. Novel 2,4-Diarylanninopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities[J]. ACS MEDICINAL CHEMISTRY LETTERS,2014,5(4):304-308. |
| APA | Liu, Zhiqing.,Ai, Jing.,Peng, Xia.,Song, Zilan.,Wu, Kui.,...&Zhang, Ao.(2014).Novel 2,4-Diarylanninopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities.ACS MEDICINAL CHEMISTRY LETTERS,5(4),304-308. |
| MLA | Liu, Zhiqing,et al."Novel 2,4-Diarylanninopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities".ACS MEDICINAL CHEMISTRY LETTERS 5.4(2014):304-308. |
入库方式： OAI收割
来源：上海药物研究所
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