Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents
文献类型：期刊论文
| 作者 | Guo, Bin1 ; Fan, Houxing1; Xin, Qisheng1; Chu, Wenjing1; Wang, Hui2; Yang, Yushe1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 23期号:13页码:3697-3699 |
| 关键词 | Benzoxazinyl-oxazolidinone Linezolid Antibacterial agents Gram-positive organisms |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2013.05.023 |
| 文献子类 | Article |
| 英文摘要 | A number of benzoxazinyl-oxazolidinones bearing 3-trizolylmethyl or 3-carboxamide side chain were designed and synthesized with the aim to develop antibacterial agents with improved properties. In vitro antibacterial activities of these novel compounds were evaluated against a panel of resistant and susceptible Gram-positive bacteria. Most analogues bearing 3-trizolylmethyl showed good to moderate antibacterial activities. Compound 12a exhibited a fourfold increase in activity compared with linezolid against all the tested strains, which was identified to be a promising antibacterial agent for further evaluation. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | RESISTANT ENTEROCOCCUS-FAECIUM ; INFECTIOUS-DISEASES SOCIETY ; MONOAMINE-OXIDASE-A ; LINEZOLID-RESISTANT ; INHIBITORS ; AMERICA |
| 资助项目 | National Natural Science Foundation of China[81172922] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000320702900002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277561]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yushe |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 200031, Peoples R China; 2.China Pharmaceut Univ, Dept Microbiol, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Bin,Fan, Houxing,Xin, Qisheng,et al. Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(13):3697-3699. |
| APA | Guo, Bin,Fan, Houxing,Xin, Qisheng,Chu, Wenjing,Wang, Hui,&Yang, Yushe.(2013).Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(13),3697-3699. |
| MLA | Guo, Bin,et al."Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.13(2013):3697-3699. |
入库方式： OAI收割
来源：上海药物研究所
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