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Structure and activation of rhodopsin

文献类型：期刊论文

作者Zhou, X. Edward1; Melcher, Karsten1; Xu, H. Eric1,2
刊名ACTA PHARMACOLOGICA SINICA
出版日期2012-03
卷号33期号:3页码:291-299
关键词G-protein-coupled receptor (GPCR) rhodopsin crystal structure photoactivation transduction
ISSN号1671-4083
DOI10.1038/aps.2011.171
文献子类Review
英文摘要Rhodopsin is the first G-protein-coupled receptor (GPCR) with its three-dimensional structure solved by X-ray crystallography. The crystal structure of rhodopsin has revealed the molecular mechanism of photoreception and signal transduction in the visual system. Although several other GPCR crystal structures have been reported over the past few years, the rhodopsin structure remains an important model for understanding the structural and functional characteristics of other GPCRs. This review summarizes the structural features, the photoactivation, and the G protein signal transduction of rhodopsin.
WOS关键词DOMINANT RETINITIS-PIGMENTOSA ; PROTEIN-COUPLED RECEPTOR ; ANGSTROM CRYSTAL-STRUCTURE ; LIGAND-BINDING ; DISULFIDE BOND ; RETINAL CONFORMATION ; INTRADISCAL DOMAIN ; BOVINE RHODOPSIN ; DRUG DISCOVERY ; MUTATIONS
资助项目Jay and Betty Van Andel Foundation[00000000] ; National Institute of Health[GM087413]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000301187300002
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/278165]  
专题药物靶标结构与功能中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhou, X. Edward
作者单位1.Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Struct & Funct Drug Targets, VARI SIMM Ctr,State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, X. Edward,Melcher, Karsten,Xu, H. Eric. Structure and activation of rhodopsin[J]. ACTA PHARMACOLOGICA SINICA,2012,33(3):291-299.
APA Zhou, X. Edward,Melcher, Karsten,&Xu, H. Eric.(2012).Structure and activation of rhodopsin.ACTA PHARMACOLOGICA SINICA,33(3),291-299.
MLA Zhou, X. Edward,et al."Structure and activation of rhodopsin".ACTA PHARMACOLOGICA SINICA 33.3(2012):291-299.

入库方式： OAI收割

来源：上海药物研究所

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