Synthesis and biological evaluation of novel piperidin-4-ol derivatives
文献类型：期刊论文
| 作者 | Weng, Zhiyong1; Wei, Wei2; Dong, Xiaowu1; Hu, Yongzhou1; Huang, Shufang1; Liu, Tao1; Xie, Xin2
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| 刊名 | MONATSHEFTE FUR CHEMIE
 |
| 出版日期 | 2012-02 |
| 卷号 | 143期号:2页码:303-308 |
| 关键词 | Piperidin-4-ol HIV CCR5 Heterocycles Ketones Reductions |
| ISSN号 | 0026-9247 |
| DOI | 10.1007/s00706-011-0645-9 |
| 文献子类 | Article |
| 英文摘要 | A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by H-1 NMR, C-13 NMR, MS, and elemental analysis. The CCR5 antagonistic activities of the compounds have also been evaluated. |
| WOS关键词 | ASYMMETRIC-SYNTHESIS ; CCR5 ; ANTAGONISTS ; INFECTION |
| 资助项目 | National Natural Science Foundation of China[81072515] ; National Natural Science Foundation of China[90713047] ; National Key Tech Project for Major Creation of New drugs[2009ZX09501-003] ; Ministry of Science and Technology[2009ZX09302-001] ; Shanghai Commission of Science and Technology[08DZ2291300] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000299179700019 |
| 出版者 | SPRINGER WIEN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278210]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Tao |
| 作者单位 | 1.Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Zhejiang, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Weng, Zhiyong,Wei, Wei,Dong, Xiaowu,et al. Synthesis and biological evaluation of novel piperidin-4-ol derivatives[J]. MONATSHEFTE FUR CHEMIE,2012,143(2):303-308. |
| APA | Weng, Zhiyong.,Wei, Wei.,Dong, Xiaowu.,Hu, Yongzhou.,Huang, Shufang.,...&Xie, Xin.(2012).Synthesis and biological evaluation of novel piperidin-4-ol derivatives.MONATSHEFTE FUR CHEMIE,143(2),303-308. |
| MLA | Weng, Zhiyong,et al."Synthesis and biological evaluation of novel piperidin-4-ol derivatives".MONATSHEFTE FUR CHEMIE 143.2(2012):303-308. |
入库方式： OAI收割
来源：上海药物研究所
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