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Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases
文献类型：期刊论文
| 作者 | Soon, Fen-Fen1,2; Ng, Ley-Moy1,2; Zhou, X. Edward1; West, Graham M.3; Kovach, Amanda1; Tan, M. H. Eileen1,2; Suino-Powell, Kelly M.1; He, Yuanzheng1; Xu, Yong1; Chalmers, Michael J.3 |
| 刊名 | SCIENCE
 |
| 出版日期 | 2012-01-06 |
| 卷号 | 335期号:6064页码:85-88 |
| ISSN号 | 0036-8075 |
| DOI | 10.1126/science.1215106 |
| 文献子类 | Article |
| 英文摘要 | Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites. |
| WOS关键词 | 2C PROTEIN PHOSPHATASES ; ABSCISIC-ACID ; GUARD-CELLS ; ACTIVATION ; PHOSPHORYLATION ; ARABIDOPSIS ; MECHANISMS ; CHANNEL ; OST1 ; PAIR |
| 资助项目 | Michigan Economic Development Corporation[00000000] ; Office of Science of the U.S. Department of Energy[00000000] ; Jay and Betty Van Andel Foundation[00000000] ; Amway (China) Limited[00000000] ; NIH[00000000] ; NSF[IOS-0820508] ; Singapore Biomedical Research Council[00000000] ; NUS Graduate School for Integrative Sciences and Engineering (NGS)[00000000] ; National Institute for General Medical Studies[GM084041] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000298846200056 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278224]  |
| 专题 | 药物靶标结构与功能中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 |
| 通讯作者 | Melcher, Karsten |
| 作者单位 | 1.Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA; 2.Natl Univ Singapore, Dept Obstet & Gynecol, Yong Loo Lin Sch Med, Natl Univ Hosp, Singapore 119228, Singapore; 3.Scripps Res Inst, Dept Mol Therapeut, Translat Res Inst, Jupiter, FL 33458 USA; 4.Northwestern Univ, Dept Mol Pharmacol & Biol Chem, Life Sci Collaborat Access Team, Synchrotron Res Ctr, Argonne, IL 60439 USA; 5.Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47907 USA; 6.Chinese Acad Sci, Ctr Drug Discovery & Design, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 7.Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA; 8.Chinese Acad Sci, VARI SIMM Ctr, Ctr Struct & Funct Drug Targets, State Key Lab Drug Res,Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Soon, Fen-Fen,Ng, Ley-Moy,Zhou, X. Edward,et al. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases[J]. SCIENCE,2012,335(6064):85-88. |
| APA | Soon, Fen-Fen.,Ng, Ley-Moy.,Zhou, X. Edward.,West, Graham M..,Kovach, Amanda.,...&Xu, H. Eric.(2012).Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases.SCIENCE,335(6064),85-88. |
| MLA | Soon, Fen-Fen,et al."Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases".SCIENCE 335.6064(2012):85-88. |
入库方式： OAI收割
来源：上海药物研究所
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