Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors
文献类型：期刊论文
| 作者 | He, Xiao-Peng1,2,3,5; Li, Cui1,2,3; Wang, Zhi-Zhou1,2,3; Gao, Li-Xin1,2,3; Shi, Xiao-Xin1,2,3; Tang, Yun1,2,3; Xie, Juan5; Li, Jia4 ; Chen, Guo-Rong1,2,3; Chen, Kaixian1,2,3,4
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| 刊名 | GLYCOCONJUGATE JOURNAL
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| 出版日期 | 2011-10 |
| 卷号 | 28期号:7页码:493-497 |
| 关键词 | Epimer Sugar template PTP inhibitor Click chemistry Molecular docking study |
| ISSN号 | 0282-0080 |
| DOI | 10.1007/s10719-011-9347-0 |
| 文献子类 | Article |
| 英文摘要 | There has been increasing interest in the development of drug candidates based on sugar templates that possess rich structural and, especially, configurational diversities. We disclose herein that the epimeric identity between methyl 3,4-bis-phenylalanyl/tyrosinyl triazolyl-alpha-D-galactopyranoside and glucopyranoside may lead to their distinct inhibitory effects on specific protein tyrosine phosphatases (PTPs). Subsequently performed molecular docking study elucidated the plausible binding behaviors of the more potent galactosyl inhibitors with their primary PTP target, i.e. Cell Division Cycle 25B (CDC25B) phosphatase. |
| WOS关键词 | CLICK CHEMISTRY ; TERMINAL ALKYNES ; AZIDES |
| 资助项目 | National Natural Science Foundation of China[20876045] ; National Natural Science Foundation of China[30801405] ; National Basic Research Program of China[2007CB914201] ; Shanghai Science and Technology Community[10410702700] ; Chinese Academy of Sciences[KSCX2-EW-R-15] ; Fundamental Research Funds for the Central Universities[WK1013002] ; French Embassy in PR China[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000297745200007 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278373]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 药物安全性评价中心 |
| 通讯作者 | Chen, Guo-Rong |
| 作者单位 | 1.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 2.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Natl Ctr Drug Screening, State Key Lab Drug Res,Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 5.CNRS, PPSM, Inst Alembert, ENS Cachan,UMR 8531, F-94235 Cachan, France |
| 推荐引用方式 GB/T 7714 | He, Xiao-Peng,Li, Cui,Wang, Zhi-Zhou,et al. Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors[J]. GLYCOCONJUGATE JOURNAL,2011,28(7):493-497. |
| APA | He, Xiao-Peng.,Li, Cui.,Wang, Zhi-Zhou.,Gao, Li-Xin.,Shi, Xiao-Xin.,...&Chen, Kaixian.(2011).Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors.GLYCOCONJUGATE JOURNAL,28(7),493-497. |
| MLA | He, Xiao-Peng,et al."Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors".GLYCOCONJUGATE JOURNAL 28.7(2011):493-497. |
入库方式： OAI收割
来源：上海药物研究所
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