Application of Nickel(II) Complexes to the Efficient Synthesis of alpha- or beta-Amino Acids
文献类型：期刊论文
| 作者 | Wang, Jiang ; Zhang, Lei; Jiang, Hualiang; Chen, Kaixian; Liu, Hong
|
| 刊名 | CHIMIA
 |
| 出版日期 | 2011 |
| 卷号 | 65期号:12页码:919-924 |
| 关键词 | Amino acids C-alkylation reaction Mannich reaction Michael reaction Nickel(II) complex Suzuki reaction |
| ISSN号 | 0009-4293 |
| DOI | 10.2533/chimia.2011.919 |
| 文献子类 | Article |
| 英文摘要 | Nonproteinogenic alpha- or beta-amino acids have attracted tremendous attention, as they are widely utilized for biological, biochemical, pharmaceutical, and asymmetric chemical investigations. Recently, we developed a series of new strategies for preparing achiral and chiral nickel(II) complexes for the synthesis of amino acids. We applied these new methods utilizing chiral nickel(II) complexes for the asymmetric Mannich reaction to synthesize enantiopure alpha,beta-diamino acids, the enantioselective tandem conjugate addition-elimination reaction to prepare glutamic acid derivatives, the Suzuki coupling reaction to yield beta(2)-amino acid derivatives, the asymmetric Mannich reaction to synthesize 3-aminoaspartate, the asymmetric Michael addition reaction to give beta-substituted-alpha,gamma-diaminobutyric acid derivatives, the asymmetric alkylation reaction to prepare linear omega-trifluoromethyl containing amino acids, and the asymmetric Michael addition reaction to synthesize syn-beta-substituted tryptophans. |
| WOS关键词 | MICHAEL ADDITION-REACTIONS ; ACTIVATED ALLYLIC ACETATES ; VIRTUALLY COMPLETE CONTROL ; PHASE-TRANSFER CONDITIONS ; ASYMMETRIC-SYNTHESIS ; NUCLEOPHILIC GLYCINE ; ENANTIOSELECTIVE SYNTHESIS ; NI(II) COMPLEX ; GLUTAMIC ACIDS ; STEREOCONTROLLED SYNTHESIS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000298835800006 |
| 出版者 | SWISS CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278643]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jiang,Zhang, Lei,Jiang, Hualiang,et al. Application of Nickel(II) Complexes to the Efficient Synthesis of alpha- or beta-Amino Acids[J]. CHIMIA,2011,65(12):919-924. |
| APA | Wang, Jiang,Zhang, Lei,Jiang, Hualiang,Chen, Kaixian,&Liu, Hong.(2011).Application of Nickel(II) Complexes to the Efficient Synthesis of alpha- or beta-Amino Acids.CHIMIA,65(12),919-924. |
| MLA | Wang, Jiang,et al."Application of Nickel(II) Complexes to the Efficient Synthesis of alpha- or beta-Amino Acids".CHIMIA 65.12(2011):919-924. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。