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Design and Synthesis of Biotinylated Troglitazone as an Active Affinity Probe

文献类型：期刊论文

作者Li Xin1,2; Li Xiaoqi3; Tang Hong3; Nan Fajun1
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2010-11
卷号28期号:11页码:2240-2244
关键词antitumor agent molecular mechanism structure-activity relationship biotinylated probe affinity chromatography
ISSN号1001-604X
DOI10.1002/cjoc.201090370
文献子类Article
英文摘要A biotin-tagged analogue of troglitazone was designed, synthesized and applied to affinity chromatography to pulldown EGFR from 293T cell lysates overexpressing EGFR, a membrane protein assumed to be troglitazone's direct binding target by previous work. The results indicate the feasibility of the biotinylated probe as a vigorous tool to clarify the molecular mechanisms for troglitazone's antitumor activities.
WOS关键词HUMAN PROSTATE-CANCER ; RECEPTOR-GAMMA ; PPAR-GAMMA ; IN-VITRO ; LIGAND ; GROWTH ; CELLS ; APOPTOSIS ; THIAZOLIDINEDIONES ; INHIBITION
资助项目National Natural Science Foundation of China[30725049] ; National Natural Science Foundation of China[90813037] ; National Natural Science Foundation of China[30721005]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:4073555
WOS记录号WOS:000285261700022
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/278736]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药理学第一研究室
通讯作者Nan Fajun
作者单位1.Shanghai Inst Mat Med, State Key Lab Drug Res, Chinese Natl Ctr Drug Screening, Shanghai 201203, Peoples R China;
2.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China;
3.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Li Xin,Li Xiaoqi,Tang Hong,et al. Design and Synthesis of Biotinylated Troglitazone as an Active Affinity Probe[J]. CHINESE JOURNAL OF CHEMISTRY,2010,28(11):2240-2244.
APA Li Xin,Li Xiaoqi,Tang Hong,&Nan Fajun.(2010).Design and Synthesis of Biotinylated Troglitazone as an Active Affinity Probe.CHINESE JOURNAL OF CHEMISTRY,28(11),2240-2244.
MLA Li Xin,et al."Design and Synthesis of Biotinylated Troglitazone as an Active Affinity Probe".CHINESE JOURNAL OF CHEMISTRY 28.11(2010):2240-2244.

入库方式： OAI收割

来源：上海药物研究所

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