机构

• 上海药物研究所 [65]
• 生物物理研究所 [2]
• 大连化学物理研究所 [2]
• 上海营养与健康研究所 [2]

采集方式

• OAI收割 [71]

内容类型

• 期刊论文 [70]
• 会议论文 [1]

发表日期

• 2024 [1]
• 2023 [3]
• 2022 [6]
• 2021 [4]
• 2020 [1]
• 2019 [1]
• 更多

学科主题

• Immunology [2]
• Cell Biolo... [1]
• Chemistry,... [1]

筛选

浏览/检索结果: 共71条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18 作者:  Zhuo, Ning;  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Yin, Jianpeng   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Type 2 Diabetes  TGR5 agonist  Betulinic acid  Gut-restricted  Gallbladder-filling effects  Kinetophores   Design and Synthesis Studies of α-Methylene-γ-butyrolactones Antagonists of GPR52 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 43, 期号: 11, 页码: 3916-3929 作者:  Shen, Donghang;  Li, Xin;  Guo, Shimeng;  Xie, Xin;  Nan, Fajun   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/02/27 Huntingdon's disease  G protein-coupled receptor  GPR52  alpha-methylene-gamma-butyrolactones  antagonist   Ligand activation mechanisms of human KCNQ2 channel 期刊论文  OAI收割 Nature communications, 2023, 卷号: 14, 期号: 1, 页码: 6632 作者:  Ma, Demin;  Zheng, Yueming;  Li, Xiaoxiao;  Zhou, Xiaoyu;  Yang, Zhenni   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/03/26 Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 2, 页码: 739-753 作者:  Xie, Zhifu;  Zhang, Mei;  Song, Qian;  Cheng, Long;  Zhang, Xinwen   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 Hypercholesterolemia  Atherosclerosis  Liver  ATP-Citrate lyase (ACLY)  Lipogenesis  Cholesterol efflux  ACLY inhibitor   Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation 期刊论文  OAI收割 NEUROBIOLOGY OF DISEASE, 2022, 卷号: 174, 页码: 10 作者:  Tian, Fuyun;  Cao, Birong;  Xu, Haiyan;  Zhan, Li;  Nan, Fajun   |  收藏  |  浏览/下载：25/0  |  提交时间：2022/12/13 KCNQ2  Epilepsy  Mouse model  HN37 (pynegabine)   Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 21 作者:  Zhang, Chenlu;  Liu, Yameng;  Wang, Ying;  Ge, Xie;  Jiao, Tingying   |  收藏  |  浏览/下载：34/0  |  提交时间：2022/11/11 Discovery and Structure-Activity Relationship Studies of Thiazole-Oxazole Tandem Heterocyclic RNA Splicing Inhibitors 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 9, 页码: 2925-2939 作者:  Zhang Rong;  Gao Xiang;  Chen Lingling;  Nan Fajun   |  收藏  |  浏览/下载：16/0  |  提交时间：2022/12/13 splicing inhibitors  circmCherry-expression system  Leucamide A derivatives  structure-activity relationships   The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKK? and overcomes gefitinib resistance in non-small cell lung cancer 期刊论文  OAI收割 CANCER BIOLOGY & MEDICINE, 2022, 卷号: 19, 期号: 8, 页码: 1172-1192 作者:  He, Ting;  Gao, Yinglei;  Fang, Yanfen;  Zhang, Yangming;  Zhang, Shuwei   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/03/21 HDAC inhibitor  c-Met  IKK?  NSCLC  gefitinib   Protecting-Group-Free One-Step Palladium-Catalyzed Coupling on C25 of Cucurbitacin B Expands Chemical Diversity with Improved Cytotoxicity against A549 Cells 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2022, 页码: 5 作者:  Zhuo, Ning;  Ma, Jie;  Cao, Lei;  Chen, Linhai;  Nan, Fajun   |  收藏  |  浏览/下载：26/0  |  提交时间：2022/08/16 Natural products  Cucurbitacin B  Palladium-catalyzed couplingl Divergent synthesis  Structure-activity relationships   Construction of the Hexacyclic Core of Dispirocochlearoids A-C via a Diels-Alder Reaction 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2022, 页码: 5 作者:  Fu, Qiang;  Wang, Yonghui;  Nan, Fajun   |  收藏  |  浏览/下载：24/0  |  提交时间：2022/06/15 Natural products  Dispirocochlearoids  Hexacyclic skeleton  Cycloaddition  Total synthesis