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ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN

文献类型：期刊论文

作者Xin, Xuelei1,2,3; Wang, Qi4; Aisa, Haji Akber2; Wang, Hanqing1
刊名JOURNAL OF FOOD BIOCHEMISTRY
出版日期2010-08
卷号34期号:4页码:811-824
ISSN号0145-8884
DOI10.1111/j.1745-4514.2009.00318.x
文献子类Article
英文摘要Nigella glandulifera Freyn, an annual plant species of the family Ranunculaceae, served as a traditional Uigur medicine and food. Many researchers have reported that Nigella sativa L., which is the same genus with it, has an antidiabetic effect, the seeds oil was an activity component used as a kind of function food. In the present study, the difference of oil extract between n-hexane and petroleum ether respectively from the seeds of Nigella glandulifera Freyn were analyzed by gas chromatography-mass spectrometry, all of them can inhibit protein tyrosine phosphatase 1B (PTP1B) with half maximal inhibitory concentration values of 33.15 +/- 0.77 and 18.50 +/- 0.52 mg/mL, respectively. They have different binding sites with PTP1B. Lastly, inhibited ability of PTP1B and that of TCPTP were compared; all of them have shown some selectivity.
WOS关键词SATIVA L. OIL ; FIXED OIL ; PTP1B ; RATS ; MICE
资助项目Foundation of the Chinese Academy of Sciences[KSCX2-YW-R-132] ; High technology and development program of Xinjiang Uigur Autonomous Region[200515123] ; Department of Science and Technology of Xinjiang Uigur Autonomous Region[200721110]
WOS研究方向Biochemistry & Molecular Biology ; Food Science & Technology
语种英语
出版者WILEY
WOS记录号WOS:000280643000008
源URL[http://119.78.100.183/handle/2S10ELR8/278815]  
专题新药研究国家重点实验室
中科院受体结构与功能重点实验室
通讯作者Aisa, Haji Akber
作者单位1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China;
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China;
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China;
4.Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Xin, Xuelei,Wang, Qi,Aisa, Haji Akber,et al. ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN[J]. JOURNAL OF FOOD BIOCHEMISTRY,2010,34(4):811-824.
APA Xin, Xuelei,Wang, Qi,Aisa, Haji Akber,&Wang, Hanqing.(2010).ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN.JOURNAL OF FOOD BIOCHEMISTRY,34(4),811-824.
MLA Xin, Xuelei,et al."ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN".JOURNAL OF FOOD BIOCHEMISTRY 34.4(2010):811-824.

入库方式： OAI收割

来源：上海药物研究所

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