Inhibition of Mixture of Lucid Garoderma and Lucid Garoderma Spore on Tumor Cell In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Chen Lingji; Han Jiaxian; Yang Weiyi; Lu Lijuan; Zhang Jialiu; Yang Qiulong; Yuan Shengtao; Ding Jian
|
| 刊名 | Cancer
 |
| 出版日期 | 2002 |
| 卷号 | 21期号:12页码:1341-1344 |
| 关键词 | garoderma antitumor nude mice xenograft |
| ISSN号 | 1000-467X |
| 其他题名 | 灵芝精粉和孢子粉混合物抑制肿瘤细胞生长的实验研究 |
| 文献子类 | Article |
| 英文摘要 | Background & Objective: Garoderma lucidum (lingzhi) is a kind of medicinal fungus with a long history in China as valuable tonic folk remedy. It has been demonstrated that lingzhi had growth inhibition effect against implanted mice tumors. It is generally regarded that anti-tumor action of lingzhi is induced by promoting function of immune system. Recently, we found that mixture of lucid garoderma and lucid garoderma spore (MLGLGS) could markedly inhibit activities of topoisomerase I and II, so this study was designed to further evaluate the inhibition effects of MLGLGS on tumor cell in vitro and in vivo. Method: Inhibition of MLGLGS on tumor cell were detected by MTT or SRB method in vitro study and by human tumor nude mice xenografts as models in vivo study. Results: Among them, the IC_(50) values were lower than 2 mg/ml in P388, U-937, and HL-60 leukemias, and lower than 4 mg/ml in 2 human lung cancer and 2 human gastric cancer cells, respectively. In vivo study revealed that MLGLGS had certain experimental therapeutic action on human lung tumor xenograft LAX-83 (dose: 1 g/kg, inhibitory rate: 49.47%) and gastric xenograft SGC-7901 (dose: 2 g/kg, inhibitory rate: 43.09%). Conclusion: MLGLGS has inhibitory action on tumor cell at high concentration and high dosage. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1007848 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268500]  |
| 专题 | 药理学第一研究室 成果转移转化处 |
| 通讯作者 | Ding Jian |
| 作者单位 | Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China. |
| 推荐引用方式 GB/T 7714 | Chen Lingji,Han Jiaxian,Yang Weiyi,et al. Inhibition of Mixture of Lucid Garoderma and Lucid Garoderma Spore on Tumor Cell In Vitro and In Vivo[J]. Cancer,2002,21(12):1341-1344. |
| APA | Chen Lingji.,Han Jiaxian.,Yang Weiyi.,Lu Lijuan.,Zhang Jialiu.,...&Ding Jian.(2002).Inhibition of Mixture of Lucid Garoderma and Lucid Garoderma Spore on Tumor Cell In Vitro and In Vivo.Cancer,21(12),1341-1344. |
| MLA | Chen Lingji,et al."Inhibition of Mixture of Lucid Garoderma and Lucid Garoderma Spore on Tumor Cell In Vitro and In Vivo".Cancer 21.12(2002):1341-1344. |
入库方式： OAI收割
来源：上海药物研究所
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