Advances in HIV-1 Integrase Inhibitors Directed toward Different Steps of Integration
文献类型：期刊论文
| 作者 | Zeng Lifan; Long Yaqiu |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2009-04 |
| 卷号 | 29期号:4页码:536-547 |
| 关键词 | HIV-1 integrase inhibitor anti-HIV drug raltegravir (MK-0518) GS-9137 |
| ISSN号 | 0253-2786 |
| 文献子类 | Article |
| 英文摘要 | Based on the mode of action, the present paper reviews the HIV-1 integrase inhibitors reported recently with respect to the structure features, pharmacophore analysis, chemical synthesis and the development status, according to the categories of strand transfer inhibitor, IN-DNA interaction inhibitor, 3'-processing inhibitor, non-specific inhibitor and peptide inhibitor, respectively. The strand transfer inhibitor is the most developed class of HIV-1 integrase inhibitors, among which MK-0518 was the first FDA-approved HIV-1 integrase inhibitor as anti-HIV drug. HIV-1 integrase inhibitor has enriched the highly active antiretroviral therapy (HAART) regimen and provides an efficient treatment for multiple drug-resistant patients. |
| WOS关键词 | IMMUNODEFICIENCY-VIRUS TYPE-1 ; ACTIVE ANTIRETROVIRAL THERAPY ; HIGHLY EFFICIENT PREPARATION ; STYRYLQUINOLINE DERIVATIVES ; REVERSE-TRANSCRIPTASE ; PEPTIDE INHIBITORS ; VIRAL REPLICATION ; DESIGN ; MECHANISM ; BINDING |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3640621 |
| WOS记录号 | WOS:000265896400005 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279276]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zeng Lifan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng Lifan,Long Yaqiu. Advances in HIV-1 Integrase Inhibitors Directed toward Different Steps of Integration[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2009,29(4):536-547. |
| APA | Zeng Lifan,&Long Yaqiu.(2009).Advances in HIV-1 Integrase Inhibitors Directed toward Different Steps of Integration.CHINESE JOURNAL OF ORGANIC CHEMISTRY,29(4),536-547. |
| MLA | Zeng Lifan,et al."Advances in HIV-1 Integrase Inhibitors Directed toward Different Steps of Integration".CHINESE JOURNAL OF ORGANIC CHEMISTRY 29.4(2009):536-547. |
入库方式： OAI收割
来源：上海药物研究所
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