Current Strategies for the Discovery of K+ Channel Modulators
文献类型：期刊论文
| 作者 | Ye, Deju2; Wang, Jiang2 ; Yu, Kunqian2; Zhou, Yu2; Jiang, Hualiang1,2; Chen, Kaixian2; Liu, Hong2
|
| 刊名 | CURRENT TOPICS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2009-03 |
| 卷号 | 9期号:4页码:348-361 |
| 关键词 | Potassium channels modulator blocker opener virtual screening chemistry strategy MAOS |
| ISSN号 | 1568-0266 |
| DOI | 10.2174/156802609788317865 |
| 文献子类 | Review |
| 英文摘要 | Potassium ion (K+) channels consist of a ubiquitous family of membrane proteins that play critical roles in a wide variety of physiological processes, such as the regulation of neuronal excitability, muscle contraction, cell proliferation, and insulin secretion. Due to their pivotal functions in biological systems, K+ channels have long been attractive targets for the rational drug design on the basis of their structures and interaction mechanisms. Various small-molecular compounds and toxins have been discovered to act as K+ channel modulators. In the present review, we will first briefly discuss current knowledge of the structures and functions of K+ channels, and then review the recent strategies for the discovery of K+ channel modulators, focusing especially on the virtual screening approaches and chemical synthesis technologies. |
| WOS关键词 | KV1.5 POTASSIUM CHANNEL ; DRUG DISCOVERY ; ION CHANNELS ; 1,4-BENZOXAZINE DERIVATIVES ; ELECTROPHYSIOLOGICAL ASSAY ; DYNAMICS SIMULATIONS ; MOLECULAR DIVERSITY ; CRYSTAL-STRUCTURE ; NATURAL-PRODUCTS ; SCORPION TOXINS |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; international collaboration projects[2007DFB30370/20061334] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000266521900005 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279301]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Ctr Drug Discovery & Desig, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ye, Deju,Wang, Jiang,Yu, Kunqian,et al. Current Strategies for the Discovery of K+ Channel Modulators[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2009,9(4):348-361. |
| APA | Ye, Deju.,Wang, Jiang.,Yu, Kunqian.,Zhou, Yu.,Jiang, Hualiang.,...&Liu, Hong.(2009).Current Strategies for the Discovery of K+ Channel Modulators.CURRENT TOPICS IN MEDICINAL CHEMISTRY,9(4),348-361. |
| MLA | Ye, Deju,et al."Current Strategies for the Discovery of K+ Channel Modulators".CURRENT TOPICS IN MEDICINAL CHEMISTRY 9.4(2009):348-361. |
入库方式： OAI收割
来源：上海药物研究所
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