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Synthesis and biological activity of novel shikonin analogues

文献类型：期刊论文

作者Wang, Wenjing2; Dai, Mei1; Zhu, Caihua1; Zhang, Jiangang2; Lin, Liping1; Ding, Jian1; Duan, Wenhu2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2009-02-01
卷号19期号:3页码:735-737
关键词Shikonin analogue Synthesis Cytotoxicity Hypoxia-inducible factor 1 alpha
ISSN号0960-894X
DOI10.1016/j.bmcl.2008.12.032
文献子类Article
英文摘要A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity against various cancer cell lines. Additionally, some analogues were also found to have the ability to decrease the expression level of HIF-1 alpha in breast cancer cells MDA-MB-231 under hypoxia. The features of these analogues suggest their potential in cancer therapy. (C) 2008 Elsevier Ltd. All rights reserved.
WOS关键词METHOXY-N-METHYLAMIDES ; NAPHTHOQUINONE DERIVATIVES ; TOPOISOMERASE-I ; INHIBITION ; CHEMISTRY ; ALKANNIN
资助项目National Science Foundation of China[0801031005] ; National Science Foundation of China[0801281005] ; Chinese National Programs for High Technology Research and Development[0604071005] ; Chinese National Programs for High Technology Research and Development[0704051005]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000262707000034
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/279325]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药理学第一研究室
通讯作者Ding, Jian
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Wenjing,Dai, Mei,Zhu, Caihua,et al. Synthesis and biological activity of novel shikonin analogues[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(3):735-737.
APA Wang, Wenjing.,Dai, Mei.,Zhu, Caihua.,Zhang, Jiangang.,Lin, Liping.,...&Duan, Wenhu.(2009).Synthesis and biological activity of novel shikonin analogues.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(3),735-737.
MLA Wang, Wenjing,et al."Synthesis and biological activity of novel shikonin analogues".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.3(2009):735-737.

入库方式： OAI收割

来源：上海药物研究所

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