Novel Anti-Alzheimer's Dimer Bis(7)-Cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets
文献类型：期刊论文
| 作者 | Li, Wenming4; Mak, Marvin4; Jiang, Hualiang3 ; Wang, Qinwen1; Pang, Yuanping2; Chen, Kaixian3; Han, Yifan4
|
| 刊名 | NEUROTHERAPEUTICS
 |
| 出版日期 | 2009-01 |
| 卷号 | 6期号:1页码:187-201 |
| 关键词 | Bis(7)-Cognitin multiple targets neuroprotection AChE NMDA receptor |
| ISSN号 | 1933-7213 |
| DOI | 10.1016/j.nurt.2008.10.040 |
| 文献子类 | Review |
| 英文摘要 | Alzheimer's disease (AD) is a progressive and degenerative brain disorder that has emerged as one of the major public health problems in adults. Unfortunately, its molecular pathology and therapeutic strategies remain elusive. Because there are multiple factors closely indicated in the pathogenesis of AD, multiple drug therapy will be required to address the varied pathological aspects of this disease. Existing pharmacological approaches with one-molecule-one-target are limited in their ability to modify the pathology of AD. Novel therapeutics strategies comprise multifunctional compounds specifically designed to target concurrently on different sites at multifactorial etiopathogenesis of AD, thereby providing greater therapeutic efficacy. Over the past decade, our group has developed several series of dimeric acetylcholinesterase (AChE) inhibitors derived from tacrine and huperzine A, a unique anti-Alzheimer's drug originally discovered from a traditional Chinese medicinal plant. Bis(7)-Cognitin, one of our novel dimers, through inhibition of AChE, N-methyl-D-aspartate receptor, nitric oxide synthase, and amyloid precursor protein/beta-amyloid cascade concurrently, possesses remarkable neuroprotective activities. More importantly, the synergism between these targets might serve as one of the most effective therapeutic strategies to arrest/modify pathological process of AD in addition to improving the cognitive functions for AD. |
| WOS关键词 | AMYLOID-BETA-PEPTIDE ; INDUCED NEURONAL APOPTOSIS ; D-ASPARTATE RECEPTORS ; HUPERZINE-A ; ACETYLCHOLINESTERASE INHIBITOR ; TORPEDO-CALIFORNICA ; NAVIGATIONAL MEMORY ; PRECURSOR PROTEIN ; COMBAT ALZHEIMERS ; DISEASE |
| 资助项目 | Research Grants Council of Hong Kong[PolyU6441/06M] ; Research Grants Council of Hong Kong[6608/07M] ; Research Grants Council of Hong Kong[N_PolyU618/07] ; Hong Kong PolyU[G-YX96] ; Hong Kong PolyU[G-U439] ; Ministry of Science and Technology (MOST) of China[2008CB517411] ; Shenzhen Shuangbai Scheme[00000000] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000261983100016 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279400]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Han, Yifan |
| 作者单位 | 1.Ningbo Univ, Sch Med, Dept Physiol, Ningbo 315211, Zhejiang, Peoples R China 2.Mayo Fdn Med Educ & Res, Rochester, MN 55905 USA; 3.Shanghai Inst Mat Media, State Key Lab Drug Res, Ctr Drug Discovery & Design, Shanghai 201203, Peoples R China; 4.Hong Kong Polytech Univ, Inst Modern Chinese Med, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Wenming,Mak, Marvin,Jiang, Hualiang,et al. Novel Anti-Alzheimer's Dimer Bis(7)-Cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets[J]. NEUROTHERAPEUTICS,2009,6(1):187-201. |
| APA | Li, Wenming.,Mak, Marvin.,Jiang, Hualiang.,Wang, Qinwen.,Pang, Yuanping.,...&Han, Yifan.(2009).Novel Anti-Alzheimer's Dimer Bis(7)-Cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets.NEUROTHERAPEUTICS,6(1),187-201. |
| MLA | Li, Wenming,et al."Novel Anti-Alzheimer's Dimer Bis(7)-Cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets".NEUROTHERAPEUTICS 6.1(2009):187-201. |
入库方式： OAI收割
来源：上海药物研究所
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