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Self-assembly of Fluorescent Dehydroberberine Enhances Mitochondria-Dependent Antitumor Efficacy

文献类型：期刊论文

作者An, Ruibing3; Gu, Zhanni1,2; Sun, Haifeng1,2; Hu, Yuxuan3; Yan, Runqi3; Ye, Deju3; Liu, Hong1,2
刊名CHEMISTRY-A EUROPEAN JOURNAL
出版日期2018-07-11
卷号24期号:39页码:9812-9819
关键词antitumor cell imaging dehydroberberine mitochondria self-assembly
ISSN号0947-6539
DOI10.1002/chem.201801112
文献子类Article
英文摘要Selective imaging and inducing mitochondrial dysfunction in tumor cells using mitochondria-targeting probes has become as a promising approach for cancer diagnosis and therapy. Here, we report the design of a fluorescent berberine analog, dehydroberberine (DH-BBR), as a new mitochondria-targeting probe capable of self-assembling into monodisperse organic nanoparticles (DTNPs) upon integration with a lipophilic counter anion, allowing for enhanced fluorescence imaging and treatment of tumors in living mice. X-ray crystallography revealed that the self-assembly process was attributed to a synergy of different molecular interactions, including pi-pi stacking, O center dot center dot center dot pi interaction and electrostatic interaction between DH-BBR and counter anions. We demonstrated that DTNPs could efficiently enter tumor tissue following intravenous injection and enhance mitochondrial delivery of DH-BBR via an electrostatic interaction driven anion exchange process. Selective accumulation in the mitochondria capable of emitting strong fluorescence and causing mitochondrial dysfunction was achieved, enabling efficient inhibition of tumor growth in living mice. This study demonstrates promise for applying lipophilic anions to control molecular self-assembly and tune antitumor activity of mitochondria-targeting probes, which can facilitate to improve cancer treatment in vivo.
WOS关键词OVARIAN-CANCER CELLS ; IN-VIVO ; PHOTODYNAMIC THERAPY ; AMINO-ACIDS ; NANOPARTICLES ; DELIVERY ; BERBERINE ; PEPTIDES ; VITRO ; NANOSTRUCTURES
资助项目National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21775071] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81220108025] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National S&T Major Projects[2014ZX09507002-001]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000438198000018
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/279660]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Ye, Deju; Liu, Hong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
3.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China;
推荐引用方式
GB/T 7714		 An, Ruibing,Gu, Zhanni,Sun, Haifeng,et al. Self-assembly of Fluorescent Dehydroberberine Enhances Mitochondria-Dependent Antitumor Efficacy[J]. CHEMISTRY-A EUROPEAN JOURNAL,2018,24(39):9812-9819.
APA An, Ruibing.,Gu, Zhanni.,Sun, Haifeng.,Hu, Yuxuan.,Yan, Runqi.,...&Liu, Hong.(2018).Self-assembly of Fluorescent Dehydroberberine Enhances Mitochondria-Dependent Antitumor Efficacy.CHEMISTRY-A EUROPEAN JOURNAL,24(39),9812-9819.
MLA An, Ruibing,et al."Self-assembly of Fluorescent Dehydroberberine Enhances Mitochondria-Dependent Antitumor Efficacy".CHEMISTRY-A EUROPEAN JOURNAL 24.39(2018):9812-9819.

入库方式： OAI收割

来源：上海药物研究所

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