Improved synthesis of YT-14, a potent antibiotic to multidrug-resistant strains
文献类型：期刊论文
| 作者 | Wei, Jianhai1; Kong, Deyu1; Wang, Lei2; Zhang, Yinyong2; Hu, Wenhao1; Yang, Yushe2
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| 刊名 | JOURNAL OF CHEMICAL RESEARCH
 |
| 出版日期 | 2018-07 |
| 期号 | 7页码:354-360 |
| 关键词 | drug candidate YT-14 multidrug resistant Gram-negative bacteria |
| ISSN号 | 1747-5198 |
| DOI | 10.3184/174751918X15314830456124 |
| 文献子类 | Article |
| 英文摘要 | A new practical synthetic approach produced clinical drug candidate YT-14, improving the overall yield from 1.3% to 13.8%. Compared with the previous route, the new route is two steps shorter and all of the steps involve purifications without column chromatography. The advantages of this procedure include simple operating conditions and higher yields. |
| WOS关键词 | GRAM-NEGATIVE BACTERIA ; SIDEROPHORE CEPHALOSPORIN |
| 资助项目 | National Natural Science Foundation of China[81573284] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000441344800004 |
| 出版者 | SCIENCE REVIEWS 2000 LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279673]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yushe |
| 作者单位 | 1.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Jianhai,Kong, Deyu,Wang, Lei,et al. Improved synthesis of YT-14, a potent antibiotic to multidrug-resistant strains[J]. JOURNAL OF CHEMICAL RESEARCH,2018(7):354-360. |
| APA | Wei, Jianhai,Kong, Deyu,Wang, Lei,Zhang, Yinyong,Hu, Wenhao,&Yang, Yushe.(2018).Improved synthesis of YT-14, a potent antibiotic to multidrug-resistant strains.JOURNAL OF CHEMICAL RESEARCH(7),354-360. |
| MLA | Wei, Jianhai,et al."Improved synthesis of YT-14, a potent antibiotic to multidrug-resistant strains".JOURNAL OF CHEMICAL RESEARCH .7(2018):354-360. |
入库方式： OAI收割
来源：上海药物研究所
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