The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity
文献类型：期刊论文
| 作者 | Zhang, Rui1,4,5,6; Tang, Chunping4,5,6 ; Li, Yan6; Ke, Chang-Qiang4,5,6; Lin, Ge3,4,5; Xie, Hua6; Yao, Sheng4,5,6; Ye, Yang2,4,5,6
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| 刊名 | PHYTOCHEMISTRY LETTERS
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| 出版日期 | 2018-06 |
| 卷号 | 25页码:43-46 |
| 关键词 | Ericaceae Rhododendron websterianum Triterpenoids Cytotoxicity |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2018.03.015 |
| 文献子类 | Article |
| 英文摘要 | The first phytochemical investigation of the fruits of Rhododendron websterianum resulted in the isolation of two new triterpenoids, 11-dehydroxytrisnormogrol acid (1), 11-dehydroxytrisnormogrol (2), and 21 known analogues. Their structures were determined by extensive analysis of spectroscopic and mass data, as well as by comparison with those in literature. All isolates were assayed their cytotoxic activities on human hepatoma SMMC-7721 cells and human lung adenocarcinoma A549 cells. Three known compounds, dammarenediol II, lup-20(29)-ene-2 alpha,3 beta-diol, and 19,24-dihydroxyurs-12-en-3-one-28-oic acid exhibited cytotoxic activities against these two human cancer cell lines with the IC50 values in a range of 27.4-42.8 mu M. |
| WOS关键词 | GENUS RHODODENDRON ; DITERPENOIDS ; GRAYANANE ; LEAVES ; MOLLE ; CONSTITUENTS ; GRAYANOIDS ; CHINENSIS ; ROOTS ; ACID |
| 资助项目 | National Natural Science Foundation of China[81673327] ; Institutes for drug discovery and development[CASIMM0120164010] ; Youth Innovation Promotion Association CAS[00000000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000433356000010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279736]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yao, Sheng; Ye, Yang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 4.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Acad Sci, SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Hong Kong, Hong Kong, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Rui,Tang, Chunping,Li, Yan,et al. The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity[J]. PHYTOCHEMISTRY LETTERS,2018,25:43-46. |
| APA | Zhang, Rui.,Tang, Chunping.,Li, Yan.,Ke, Chang-Qiang.,Lin, Ge.,...&Ye, Yang.(2018).The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity.PHYTOCHEMISTRY LETTERS,25,43-46. |
| MLA | Zhang, Rui,et al."The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity".PHYTOCHEMISTRY LETTERS 25(2018):43-46. |
入库方式： OAI收割
来源：上海药物研究所
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