7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities
文献类型：期刊论文
| 作者 | Zheng, Yuan-Dong1,2,3,4; Bai, Gang1,2,4; Tang, Chunping2,3 ; Ke, Chang-Qiang2,3; Yao, Sheng2,3; Tong, Lin-Jiang2,4; Feng, Fang2,4; Li, Yan2,4; Ding, Jian1,2,4; Xie, Hua2,4
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2018-03 |
| 卷号 | 125页码:174-183 |
| 关键词 | Podocarpus nagi Type B nagilactone Cytotoxic activity Apoptosis |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2018.01.007 |
| 文献子类 | Article |
| 英文摘要 | A phytochemical investigation of twigs of Podocarpus nagi resulted in the identification of eight new type B nagilactones (1-8), all bearing a 7 alpha,8 alpha-epoxy-9(11)-enolide substructure, along with two known analogs (9-10). Their structures were determined on the basis of spectroscopic analysis, including HRESIMS, IR and NMR experiments, and X-ray crystallographic analysis. In vitro cytotoxic assay exhibited that compounds 1, 2, 9 and 10 could induce antiproliferation against three different types of human cancer cells while compounds 3 and 5 were inactive. Notably, the IC50 value of compound 1 is 0.208 mu M for A431 human epidermoid carcinoma cells, reaching the same level as the positive control combretastatin A-4 (0.104 mu M). Furthermore, compound 1 performed a strong inhibition of cancer cells by triggering apoptosis and arresting the cell cycle at G(1) phase. These results unfold potential anticancer therapeutic applications of type B nagilactones. |
| WOS关键词 | NATURAL-PRODUCTS ; NORDITERPENE DILACTONES ; ANTICANCER DRUGS ; DISCOVERY ; MICROTUBULES ; NAGILACTONES ; PODOLACTONES ; PACLITAXEL ; LACTONES ; GROWTH |
| 资助项目 | Institutes for drug discovery and development[CASIMM0120164010] ; Strategic Pilot Projects[XDA12040318] ; Chinese Academy of Sciences[GJHZ1678] ; Chinese Academy of Sciences[GJHZ1739] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000425560500027 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279881]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Xie, Hua; Ye, Yang |
| 作者单位 | 1.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zheng, Yuan-Dong,Bai, Gang,Tang, Chunping,et al. 7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities[J]. FITOTERAPIA,2018,125:174-183. |
| APA | Zheng, Yuan-Dong.,Bai, Gang.,Tang, Chunping.,Ke, Chang-Qiang.,Yao, Sheng.,...&Ye, Yang.(2018).7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities.FITOTERAPIA,125,174-183. |
| MLA | Zheng, Yuan-Dong,et al."7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities".FITOTERAPIA 125(2018):174-183. |
入库方式： OAI收割
来源：上海药物研究所
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