Cu(II)-catalyzed C6-selective C-H thiolation of 2-pyridones using air as the oxidant
文献类型：期刊论文
| 作者 | Peng, Panfeng1,2; Wang, Jiang1 ; Li, Chunpu1; Zhu, Wei1; Jiang, Hualiang1,2; Liu, Hong1
|
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:62页码:S7441-S7445 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra04388g |
| 文献子类 | Article |
| 英文摘要 | The Cu(II)-catalyzed and chelate-directed C6-selective C-H thiolation of 2-pyridones with disulfides was developed to provide aryl and alkyl thioethers. This transformation uses a catalytic amount of Cu(OAc)(2) and molecular oxygen in air as an oxidant, no cocatalysts or metallic oxidants are required. The reaction accommodated both electronic and steric factors at the C3-C5 positions of 2-pyridones, which is efficient for the C6 thiolation of a broad range of 2-pyridones with up to 93% yield. |
| WOS关键词 | CATALYZED DIRECTED SULFENYLATION ; DIRECT ARYLATION ; BOND-CLEAVAGE ; DIRECT ALKYLATION ; ALIPHATIC AMIDES ; C(SP(3))-H BONDS ; COPPER ; PALLADIUM ; DERIVATIVES ; FUNCTIONALIZATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000378755200092 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276217]  |
| 专题 | 药物发现与设计中心 药物化学研究室 |
| 通讯作者 | Jiang, Hualiang |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wen Hua Rd, Shenyang 110016, Liaoning, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Peng, Panfeng,Wang, Jiang,Li, Chunpu,et al. Cu(II)-catalyzed C6-selective C-H thiolation of 2-pyridones using air as the oxidant[J]. RSC ADVANCES,2016,6(62):S7441-S7445. |
| APA | Peng, Panfeng,Wang, Jiang,Li, Chunpu,Zhu, Wei,Jiang, Hualiang,&Liu, Hong.(2016).Cu(II)-catalyzed C6-selective C-H thiolation of 2-pyridones using air as the oxidant.RSC ADVANCES,6(62),S7441-S7445. |
| MLA | Peng, Panfeng,et al."Cu(II)-catalyzed C6-selective C-H thiolation of 2-pyridones using air as the oxidant".RSC ADVANCES 6.62(2016):S7441-S7445. |
入库方式： OAI收割
来源：上海药物研究所
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