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Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement

文献类型：期刊论文

作者Li, Bo2; Wang, Gaihong2; Xu, Zhijian2; Zhang, Yong2; Huang, Xiangui3; Zeng, Bubing3; Chen, Kaixian2; Shi, Jiye1; Wang, Heyao2; Zhu, Weiliang2
刊名EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
出版日期2014-04
卷号77页码:204-210
关键词[2,3] rearrangement [3,3] rearrangement 3-Arylisoquinolone Antitumor
ISSN号0223-5234
DOI10.1016/j.ejmech.2014.03.008
文献子类Article
英文摘要The present study discovers multiple N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement. The current [2,3] rearrangement of epoxy or acetal O-substituents converting to diol or alcohol N-substituents can be promoted by silica gel or by diluted hydrochloric acid, which is distinct from previously reported [2,3] rearrangements. Some of the derivatives displayed comparable or even stronger cytotoxicity than sorafenib and vemurafenib on HCT116 colon carcinoma and A375 melanoma cell lines. Therefore, the rearrangement via intramolecular carbon-oxygen bond cleavage and carbon-nitrogen bond formation should be a useful approach for developing novel anticancer drugs derived from isoquinolones. (C) 2014 Elsevier Masson SAS. All rights reserved.
WOS关键词IN-VITRO ; CANCER
资助项目Ministry of Science and Technology[2012AA01A305] ; National Major Project[2012ZX09301001-004] ; National Major Project[2013ZX09103001-001] ; National Natural Science Foundation[81273435] ; National Natural Science Foundation[81302699] ; National Natural Science Foundation[21373258]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000335874800023
出版者ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/277123]  
专题药物发现与设计中心
药理学第三研究室
通讯作者Shi, Jiye
作者单位1.UCB Pharma, Dept Informat, Slough SL1 4EN, Berks, England
2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China;
3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Bo,Wang, Gaihong,Xu, Zhijian,et al. Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2014,77:204-210.
APA Li, Bo.,Wang, Gaihong.,Xu, Zhijian.,Zhang, Yong.,Huang, Xiangui.,...&Zhu, Weiliang.(2014).Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,77,204-210.
MLA Li, Bo,et al."Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 77(2014):204-210.

入库方式： OAI收割

来源：上海药物研究所

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