The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site
文献类型：期刊论文
| 作者 | Li, Qing2,3; Qi, Jianxun2; Zhang, Wei2,4; Vavricka, Christopher J.2; Shi, Yi2,4 ; Wei, Jinhua2,4; Feng, Enguang5; Shen, Jingshan5; Chen, Jilong2; Liu, Di2,6
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| 刊名 | NATURE STRUCTURAL & MOLECULAR BIOLOGY
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| 出版日期 | 2010-10 |
| 卷号 | 17期号:10页码:1266-1268 |
| ISSN号 | 1545-9993 |
| DOI | 10.1038/nsmb.1909 |
| 文献子类 | Article |
| 英文摘要 | Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity. |
| WOS关键词 | ORIGIN INFLUENZA-VIRUS ; A VIRUSES ; HEMAGGLUTININ ; INHIBITORS ; DESIGN |
| 资助项目 | Chinese Academy of Sciences[KSCX2-YW-R-158] ; Chinese Academy of Sciences[2009Y2BS2] ; Ministry of Science and Technology of China[2010CB534004] ; Ministry of Science and Technology of China[2011CB504703] ; International Research Group of the National Natural Science Foundation of China (NSFC)[81021003] ; NSFC[31050110126] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000282563600019 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278766]  |
| 专题 | 药物化学研究室 药物发现与设计中心 |
| 通讯作者 | Gao, George F. |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China; 2.Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing, Peoples R China; 3.Univ Sci & Technol China, Coll Life Sci, Hefei 230026, Peoples R China; 4.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 6.Chinese Acad Sci, Network Informat Ctr, Inst Microbiol, Beijing, Peoples R China; 7.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qing,Qi, Jianxun,Zhang, Wei,et al. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY,2010,17(10):1266-1268. |
| APA | Li, Qing.,Qi, Jianxun.,Zhang, Wei.,Vavricka, Christopher J..,Shi, Yi.,...&Gao, George F..(2010).The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.NATURE STRUCTURAL & MOLECULAR BIOLOGY,17(10),1266-1268. |
| MLA | Li, Qing,et al."The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site".NATURE STRUCTURAL & MOLECULAR BIOLOGY 17.10(2010):1266-1268. |
入库方式： OAI收割
来源：上海药物研究所
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