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Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress

文献类型：期刊论文

作者Wang, Ting2; Sun, Peng1,2; Chen, Liang1; Huang, Qi2; Chen, Kaixian1,2; Jia, Qi1; Li, Yiming1; Wang, Heyao2
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2014-06-04
卷号62期号:22页码:5038-5045
关键词cinnamtannin D-1 pancreatic beta-cells apoptosis oxidative stress
ISSN号0021-8561
DOI10.1021/jf500387d
文献子类Article
英文摘要In previous studies, A-type procyanidin oligomers isolated from Cinnamomum tamala were proved to possess antidiabetic effect and protect pancreatic beta-cells in vivo. The aim of this study was to unveil the mechanisms of protecting pancreatic beta-cells from palmitic acid-induced apoptosis by cinnamtannin D-1 (CD1), one of the main A-type procyanidin oligomers in C. tamala. CD1 was discovered to dose-dependently reduce palmitic acid- or H2O2-induced apoptosis and oxidative stress in INS-1 cells, MIN6 cells, and primary cultured murine islets. Moreover, CD1 could reverse palmitic acid-induced dysfunction of glucose-stimulated insulin secretion in primary cultured islets. These results indicate that reduction of apoptosis and oxidative stress might account for the protection effect of CD1, which provided a better understanding of the mechanisms of the antidiabetic effects of procyanidin oligomers.
WOS关键词NITRIC-OXIDE SYNTHASE ; ENDOPLASMIC-RETICULUM STRESS ; BARK EXTRACT PYCNOGENOL(R) ; FATTY-ACID ; MITOCHONDRIAL DYSFUNCTION ; INSULIN-SECRETION ; CINNAMOMUM-CASSIA ; ACINAR-CELLS ; IN-VITRO ; INHIBITION
资助项目National Nature Science Foundation of China[81072681] ; National High Technology Research and Development Program of China ("863" Program)[2007AA02Z301] ; State Key Program of Basic Research of China grant ("973" program)[2009CB918502] ; National Science and Technology Major Project[2012ZX09301001-001]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000337018700008
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/277032]  
专题天然药物化学研究室
药理学第三研究室
通讯作者Li, Yiming
作者单位1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Wang, Ting,Sun, Peng,Chen, Liang,et al. Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2014,62(22):5038-5045.
APA Wang, Ting.,Sun, Peng.,Chen, Liang.,Huang, Qi.,Chen, Kaixian.,...&Wang, Heyao.(2014).Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,62(22),5038-5045.
MLA Wang, Ting,et al."Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62.22(2014):5038-5045.

入库方式： OAI收割

来源：上海药物研究所

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