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Synthesis and Bioevaluation of Shikonin Derivatives

文献类型：期刊论文

作者Cao, Sufen1; Zhang, Jiangang2; Duan, Wenhu1,2
刊名LETTERS IN DRUG DESIGN & DISCOVERY
出版日期2018
卷号15期号:9页码:945-950
关键词Amidation chemical stability cytotoxicity esterification shikonin derivatives synthesis SRB assay cell lines
ISSN号1570-1808
DOI10.2174/1570180815666171229152139
文献子类Article
英文摘要Background: Ester and amide derivatives of shikonin were synthesized to improve the chemical stability of shikonin. Methods: All synthesized compounds were evaluated for their antiproliferative activity against A549 cell line by SRB assay, and five of them demonstrated comparable cytotoxicity to shikonin. Results and Conclusion: The most potent compound, 22d, was more stable and potent than shikonin.
WOS关键词ANTITUMOR-ACTIVITY ; BETA-HYDROXYISOVALERYLSHIKONIN ; LITHOSPERMUM-ERYTHRORHIZON ; BIOLOGICAL EVALUATION ; IN-VIVO ; ALKANNIN ; INHIBIT ; INDUCTION ; DESIGN ; GROWTH
资助项目National Natural Science Foundation of China[81573271] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[004-013] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[011-016] ; Shanghai Science and Technology Commission[15431901300] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020303]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000438897300004
出版者BENTHAM SCIENCE PUBL LTD
源URL[http://119.78.100.183/handle/2S10ELR8/272303]  
专题药物化学研究室
通讯作者Duan, Wenhu
作者单位1.East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Materia Med, Dept Med Chem, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Sufen,Zhang, Jiangang,Duan, Wenhu. Synthesis and Bioevaluation of Shikonin Derivatives[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2018,15(9):945-950.
APA Cao, Sufen,Zhang, Jiangang,&Duan, Wenhu.(2018).Synthesis and Bioevaluation of Shikonin Derivatives.LETTERS IN DRUG DESIGN & DISCOVERY,15(9),945-950.
MLA Cao, Sufen,et al."Synthesis and Bioevaluation of Shikonin Derivatives".LETTERS IN DRUG DESIGN & DISCOVERY 15.9(2018):945-950.

入库方式： OAI收割

来源：上海药物研究所

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