Development of a Robust Process for the Preparation of High-Quality 4-Methylenepiperidine Hydrochloride
文献类型：期刊论文
| 作者 | Zhu, Fuqiang3,4; Aisa, Haji A.4; Zhang, Jian1; Hu, Tianwen1; Sun, Changliang1; He, Yang2; Xie, Yuanchao2; Shen, Jingshan2
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| 刊名 | ORGANIC PROCESS RESEARCH & DEVELOPMENT
 |
| 出版日期 | 2018-01 |
| 卷号 | 22期号:1页码:91-96 |
| ISSN号 | 1083-6160 |
| DOI | 10.1021/acs.oprd.7b00350 |
| 文献子类 | Article |
| 英文摘要 | An efficient route for the preparation of 4-methylenepiperidine hydrochloride 1 was designed, and then a process feasible for large-scale production was developed with a total yield of 83.5% at a purity of 99.9%. |
| WOS关键词 | DERIVATIVES ; EFINACONAZOLE ; AGENTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000423252100009 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272342]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Aisa, Haji A.; Shen, Jingshan |
| 作者单位 | 1.Topharman Shanghai Co Ltd, Bldg 1,388 Jialilue Rd,Zhangjiang Hitech Pk, Shanghai 201209, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Reg, Xinjiang Tech Inst Phys & Chem, South Beijing Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhu, Fuqiang,Aisa, Haji A.,Zhang, Jian,et al. Development of a Robust Process for the Preparation of High-Quality 4-Methylenepiperidine Hydrochloride[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2018,22(1):91-96. |
| APA | Zhu, Fuqiang.,Aisa, Haji A..,Zhang, Jian.,Hu, Tianwen.,Sun, Changliang.,...&Shen, Jingshan.(2018).Development of a Robust Process for the Preparation of High-Quality 4-Methylenepiperidine Hydrochloride.ORGANIC PROCESS RESEARCH & DEVELOPMENT,22(1),91-96. |
| MLA | Zhu, Fuqiang,et al."Development of a Robust Process for the Preparation of High-Quality 4-Methylenepiperidine Hydrochloride".ORGANIC PROCESS RESEARCH & DEVELOPMENT 22.1(2018):91-96. |
入库方式： OAI收割
来源：上海药物研究所
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