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Efficient, enantioselective organocatalytic synthesis of trichostatin A

文献类型：期刊论文

作者Zhang, Shilei; Duan, Wenhu; Wang, Wei
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2006-07
卷号348期号:10-11页码:1228-1234
关键词aldol reaction asymmetric organocatalysis HDAC inhibitors proline trichostatin A
ISSN号1615-4150
DOI10.1002/adsc.200606106
文献子类Article
英文摘要An efficient, highly stereocontrolled total synthesis of trichostatin A (1) has been achieved in 9 steps with 17.4% overall yield and > 99% optical purity from readily available achiral starting materials. The key features of this synthesis include the L-proline-promoted, highly enantioselective cross-aldol reaction as a crucial step for the construction of the C-6 chiral center and the minimization of racemization by final step oxidation of the OH group to a ketone at position 7.
WOS关键词ASYMMETRIC ALDOL REACTIONS ; HISTONE DEACETYLASE INHIBITORS ; ALPHA-AMINO-ACIDS ; PYRROLIDINE-SULFONAMIDE ; L-PROLINAMIDE ; CARBONYL-COMPOUNDS ; ALDEHYDES ; KETONES ; POTENT ; DERIVATIVES
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000239412400013
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/273543]  
专题药物化学研究室
通讯作者Wang, Wei
作者单位1.E China Univ Sci & Technol, Dept Med Chem, Sch Pharm, Shanghai 200237, Peoples R China
2.Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Grad Sch, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Shilei,Duan, Wenhu,Wang, Wei. Efficient, enantioselective organocatalytic synthesis of trichostatin A[J]. ADVANCED SYNTHESIS & CATALYSIS,2006,348(10-11):1228-1234.
APA Zhang, Shilei,Duan, Wenhu,&Wang, Wei.(2006).Efficient, enantioselective organocatalytic synthesis of trichostatin A.ADVANCED SYNTHESIS & CATALYSIS,348(10-11),1228-1234.
MLA Zhang, Shilei,et al."Efficient, enantioselective organocatalytic synthesis of trichostatin A".ADVANCED SYNTHESIS & CATALYSIS 348.10-11(2006):1228-1234.

入库方式： OAI收割

来源：上海药物研究所

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