Structurally diverse HIV-1 integrase inhibitors: Past, present and perspective
文献类型：期刊论文
| 作者 | Jiang, XH; Long, YQ |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2004-11 |
| 卷号 | 24期号:11页码:1380-1388 |
| 关键词 | HIV-1 integrase inhibitor beta-diketo acid antiviral agent |
| ISSN号 | 0253-2786 |
| 文献子类 | Article |
| 英文摘要 | HIV-1 integrase is an essential enzyme for retroviral replication. It is involved in the integration of HIV DNA into host chromosomal DNA and appears to have no functional equivalent in human cells. Therefore it is an attractive and rational target for selective anti-AIDS therapy. During the past 10 years a plethora of inhibitors have been identified and some were shown to be selective against IN and block viral replication. The two most predominant classes of inhibitors have been the catechol containing hydroxylated aromatics and more recently the diketoacid containing aromatics. Herein, a review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides, curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl-based compounds. For all these compounds, the important structural features essential for the inhibition of the integrase are pointed out. |
| WOS关键词 | VIRUS TYPE-1 INTEGRASE ; BETA-DIKETO ACIDS ; CHLOROPEPTIN-I ; STRUCTURE ELUCIDATION ; STRAND TRANSFER ; CELLS ; REPLICATION ; HYDROLYSIS ; ANALOGS ; BINDING |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1805452 |
| WOS记录号 | WOS:000225056600006 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273997]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Long, YQ |
| 作者单位 | Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Med Chem Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, XH,Long, YQ. Structurally diverse HIV-1 integrase inhibitors: Past, present and perspective[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2004,24(11):1380-1388. |
| APA | Jiang, XH,&Long, YQ.(2004).Structurally diverse HIV-1 integrase inhibitors: Past, present and perspective.CHINESE JOURNAL OF ORGANIC CHEMISTRY,24(11),1380-1388. |
| MLA | Jiang, XH,et al."Structurally diverse HIV-1 integrase inhibitors: Past, present and perspective".CHINESE JOURNAL OF ORGANIC CHEMISTRY 24.11(2004):1380-1388. |
入库方式： OAI收割
来源：上海药物研究所
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