Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl alpha-Amino Acid Derivatives at Room Temperature
文献类型：期刊论文
| 作者 | Li, Shuangjie2; Zhu, Wei1; Gao, Feng1; Li, Chunpu1; Wang, Jiang1 ; Liu, Hong1
|
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2017-01-06 |
| 卷号 | 82期号:1页码:126-134 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.6b02257 |
| 文献子类 | Article |
| 英文摘要 | An efficient palladium-catalyzed ortho-alkoxylation of N-benzoyl alpha-amino acid derivatives at room temperature has been explored. This novel transformation, using amino acids as directing groups, Pd(OAc)(2) as catalyst, alcohols as the alkoxylation reagents, and PhI(OAc)(2) as the oxidant, showed wide generality, good functional tolerance, and high monoselectivity and regioselectivity. |
| WOS关键词 | C-H FUNCTIONALIZATION ; DIRECTING GROUP ; UNACTIVATED C(SP(3))-H ; C(SP(2))-H BONDS ; ACTIVATION ; ARENES ; INHIBITORS ; HYDROXYLATION ; MECHANISM ; TEMPLATE |
| 资助项目 | National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[21472209] ; National Natural Science Foundation of China[91229204] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National Basic Research Program of China[2012CB518005] ; National S&T Major Projects[2013ZX09507-001] ; National S&T Major Projects[2014ZX09507002-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000391781900013 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275681]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Shuangjie,Zhu, Wei,Gao, Feng,et al. Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl alpha-Amino Acid Derivatives at Room Temperature[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(1):126-134. |
| APA | Li, Shuangjie,Zhu, Wei,Gao, Feng,Li, Chunpu,Wang, Jiang,&Liu, Hong.(2017).Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl alpha-Amino Acid Derivatives at Room Temperature.JOURNAL OF ORGANIC CHEMISTRY,82(1),126-134. |
| MLA | Li, Shuangjie,et al."Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl alpha-Amino Acid Derivatives at Room Temperature".JOURNAL OF ORGANIC CHEMISTRY 82.1(2017):126-134. |
入库方式： OAI收割
来源：上海药物研究所
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