Downregulation of stathmin 1 in human gallbladder carcinoma inhibits tumor growth in vitro and in vivo
文献类型：期刊论文
| 作者 | Wang, Jiwen6,7; Yao, Yanli7; Ming, Yue1; Shen, Sheng6; Wu, Nan2,3; Liu, Jiaqi5; Liu, Han6; Suo, Tao6; Pan, Hongtao6; Zhang, Dexiang4 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-06-28 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep28833 |
| 文献子类 | Article |
| 英文摘要 | Gallbladder carcinoma (GBC) is a highly lethal malignancy of the gastrointestinal tract. Despite extensive research, the underlying molecular mechanism of GBC remains largely unclear. Stathmin 1 (STMN1) is an important cytosolic protein associated with microtubule stability that was reported to be involved in tumorigenesis. Up to our knowledge, its role in gallbladder carcinoma has not been analyzed. In this study, we found that STMN1 was significantly highly expressed in GBC by immunohistochemistry (IHC). Further research demonstrated that silencing of STMN1 inhibited cell growth in vitro. Moreover, knockdown of STMN1 induced apoptosis and delayed G2/M phase transformation in GBC cells. Our data support a rationale for further studies that the silencing of STMN1 may regulate the activity of p38 MAPK kinase and p53/p21 signal pathway. Besides, xenografted gallbladder carcinoma cells growth were significantly impaired after STMN1 was silenced in vivo. These results suggested that STMN1 played an important role in cell proliferation and migration. This provided a potential clue for investigating the therapeutic target in GBC. |
| WOS关键词 | CELL-LINES ; CANCER ; P53 ; TARGET ; SUPPRESSOR ; EXPRESSION ; PROTEIN ; LACKING |
| 资助项目 | National Natural Science Foundation of China[81272728] ; National Natural Science Foundation of China[81502004] ; National Natural Science Foundation of China[81272722] ; State Key Program of National Natural Science Foundation of China[31230022] ; Foundation of Shanghai Science and Technology Committee[11JC1416202] ; Foundation of Shanghai Science and Technology Committee[10411955500] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000378723400001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275984]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Ding, Kan; Liu, Houbao |
| 作者单位 | 1.Chinese Acad Med Sci, Canc Hosp, Peking Union Med Coll, PET CT Ctr, Beijing 100021, Peoples R China; 2.Beijing Key Lab Genet Res Skeletal Deform, Beijing, Peoples R China; 3.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing 100730, Peoples R China; 4.Fudan Univ, Peoples Hosp Shanghai 5, Dept Gen Surg, Shanghai 200240, Peoples R China 5.Chinese Acad Med Sci, Canc Hosp, Dept Breast Surg Oncol, Beijing 100021, Peoples R China; 6.Fudan Univ, Gen Surg Inst, Zhongshan Hosp, Dept Gen Surg, Shanghai 200030, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Jiwen,Yao, Yanli,Ming, Yue,et al. Downregulation of stathmin 1 in human gallbladder carcinoma inhibits tumor growth in vitro and in vivo[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Wang, Jiwen.,Yao, Yanli.,Ming, Yue.,Shen, Sheng.,Wu, Nan.,...&Liu, Houbao.(2016).Downregulation of stathmin 1 in human gallbladder carcinoma inhibits tumor growth in vitro and in vivo.SCIENTIFIC REPORTS,6. |
| MLA | Wang, Jiwen,et al."Downregulation of stathmin 1 in human gallbladder carcinoma inhibits tumor growth in vitro and in vivo".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：上海药物研究所
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