Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review
文献类型：期刊论文
| 作者 | Xie, Yuanchao2; Ogah, Comfort Alicha1; Jiang, Xiangrui2 ; Li, Jianfeng2; Shen, Jingshan2
|
| 刊名 | CURRENT DRUG TARGETS
 |
| 出版日期 | 2016 |
| 卷号 | 17期号:13页码:1560-1576 |
| 关键词 | Hepatitis C virus inhibitor nucleoside NS5B polymerase prodrug SAR |
| ISSN号 | 1389-4501 |
| DOI | 10.2174/1389450117666151209123751 |
| 文献子类 | Review |
| 英文摘要 | Nowadays, a large number of people in the world are suffering from chronic Hepatitis C. HCV NS5B polymerase conserved across the identified 7 HCV genotypes is considered to be the most promising target in combating HCV. During the past decade, significant progress has been made in the discovery of novel nucleoside HCV NS5B polymerase inhibitors. A potent anti-HCV drug, sofosbuvir with high cure rates has been approved. Besides, quite a few nucleoside anti-HCV agents are being evaluated in clinical trials. The purpose of this review is to present recent progress in the development of nucleoside HCV NS5B polymerase inhibitors, focusing on lead compounds that hold great promise for medicinal use and their structure-activity relationships (SARs) in order to provide guidance for future drug design and discovery. |
| WOS关键词 | ANTI-HCV AGENTS ; DEPENDENT RNA-POLYMERASE ; GENOTYPE 1 INFECTION ; PHOSPHORAMIDATE PROTIDE APPROACH ; HIGHLY POTENT INHIBITORS ; BOVINE VIRAL DIARRHEA ; REPLICATION IN-VITRO ; ANTIVIRAL ACTIVITY ; PYRIMIDINE NUCLEOSIDES ; SELECTIVE INHIBITOR |
| 资助项目 | National Science Foundation for Young Scientists of China[21502209] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000387084300011 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276193]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Shen, Jingshan |
| 作者单位 | 1.Univ Lagos, Fac Pharm, Dept Pharmaceut Chem, Lagos, Lagos State, Nigeria 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xie, Yuanchao,Ogah, Comfort Alicha,Jiang, Xiangrui,et al. Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review[J]. CURRENT DRUG TARGETS,2016,17(13):1560-1576. |
| APA | Xie, Yuanchao,Ogah, Comfort Alicha,Jiang, Xiangrui,Li, Jianfeng,&Shen, Jingshan.(2016).Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review.CURRENT DRUG TARGETS,17(13),1560-1576. |
| MLA | Xie, Yuanchao,et al."Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review".CURRENT DRUG TARGETS 17.13(2016):1560-1576. |
入库方式： OAI收割
来源：上海药物研究所
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