Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes
文献类型：期刊论文
| 作者 | Li, Chunpu; Zhang, Dengyou; Zhu, Wei; Wan, Penghui; Liu, Hong
|
| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2016 |
| 卷号 | 3期号:9页码:1080-1083 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c6qo00178e |
| 文献子类 | Article |
| 英文摘要 | Pd-catalyzed direct difluoroallylation of C-H bonds of benzamides with readily available Rf-Br reagents is reported. The reaction proceeds via Pd-catalyzed C-H activation, followed by reaction of the resulting intermediate with 3-bromo-3,3-difluoropropene (BDFP) in a gamma-selective fashion. The C-H functionalization process was characterized by a broad substrate scope as well as an excellent functional-group tolerance. |
| WOS关键词 | CARBON-HYDROGEN BONDS ; CROSS-COUPLING REACTIONS ; C(SP(3))-H BONDS ; CATALYZED ARYLATION ; ALKYL-HALIDES ; PALLADIUM ; DERIVATIVES ; ALLYLATION ; ACTIVATION ; BIDENTATE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000382471800002 |
| 出版者 | CHINESE CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276204]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Chunpu,Zhang, Dengyou,Zhu, Wei,et al. Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes[J]. ORGANIC CHEMISTRY FRONTIERS,2016,3(9):1080-1083. |
| APA | Li, Chunpu,Zhang, Dengyou,Zhu, Wei,Wan, Penghui,&Liu, Hong.(2016).Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes.ORGANIC CHEMISTRY FRONTIERS,3(9),1080-1083. |
| MLA | Li, Chunpu,et al."Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes".ORGANIC CHEMISTRY FRONTIERS 3.9(2016):1080-1083. |
入库方式： OAI收割
来源：上海药物研究所
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