Palladium-Catalyzed C2-Acylation of Indoles with alpha-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group
文献类型：期刊论文
| 作者 | Li, Chunpu1,2; Zhu, Wei1; Shu, Shuangjie1; Wu, Xiaoming2; Liu, Hong1,2
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| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015-06 |
| 期号 | 17页码:3743-3750 |
| 关键词 | Synthetic methods Acylation C-H activation Palladium Nitrogen heterocycles |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201500304 |
| 文献子类 | Article |
| 英文摘要 | An effective and practical palladium-catalyzed C2-acylation method was successfully developed for the synthesis of 2-acylindoles. A variety of 2-acylindoles were readily prepared from N-pyrimidyl indoles in moderate to good yields. This methodology offers several advantages, which include ease of handling, mild reaction conditions, and use of an efficient and cheap catalyst. In particular, challenging 2-acetylindoles were synthesized in good yields. |
| WOS关键词 | C-H ACTIVATION ; OXOCARBOXYLIC ACIDS ; BOND-CLEAVAGE ; DIRECT ALKYNYLATION ; POTENT INHIBITORS ; C-2 ALKENYLATION ; DIRECT ARYLATION ; CYANIDE SOURCE ; DIRECT ACCESS ; ACYLATION |
| 资助项目 | National Natural Science Foundation of China (NSFC)[21021063] ; National Natural Science Foundation of China (NSFC)[91229204] ; National Natural Science Foundation of China (NSFC)[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] ; National S&T Major Projects[2013ZX09507-001] ; National S&T Major Projects[2014ZX09507002-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000355534600013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276513]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Wu, Xiaoming |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Chunpu,Zhu, Wei,Shu, Shuangjie,et al. Palladium-Catalyzed C2-Acylation of Indoles with alpha-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(17):3743-3750. |
| APA | Li, Chunpu,Zhu, Wei,Shu, Shuangjie,Wu, Xiaoming,&Liu, Hong.(2015).Palladium-Catalyzed C2-Acylation of Indoles with alpha-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(17),3743-3750. |
| MLA | Li, Chunpu,et al."Palladium-Catalyzed C2-Acylation of Indoles with alpha-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .17(2015):3743-3750. |
入库方式： OAI收割
来源：上海药物研究所
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