An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride
文献类型：期刊论文
| 作者 | Wu, Chunhui2; Chen, Weiming1; Jiang, Dehui1; Jiang, Xiangrui2 ; Shen, Jingshan2
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| 刊名 | ORGANIC PROCESS RESEARCH & DEVELOPMENT
 |
| 出版日期 | 2015-04 |
| 卷号 | 19期号:4页码:555-558 |
| ISSN号 | 1083-6160 |
| DOI | 10.1021/acs.oprd.5b00027 |
| 文献子类 | Article |
| 英文摘要 | 2-Chloro-6-fluorobenzaldehyde was converted to 4-(1-piperazinyl)benzo[b]thiophene dihydrochloride (18), an intermediate in the synthesis of brexpiprazole, via a five-step sequence in 54% overall yield. This procedure requires no expensive catalyst and avoids the side products produced in the coupling step in the reported process. Several kilograms of compound 18 were prepared using this economical and scalable process. |
| WOS关键词 | CARBOXYLIC-ACIDS |
| 资助项目 | Science and Technology Commission of Shanghai Municipality[14431905500] ; National Natural Science Foundation of China[81273366] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000353314900011 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276581]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Jiang, Xiangrui |
| 作者单位 | 1.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Chunhui,Chen, Weiming,Jiang, Dehui,et al. An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2015,19(4):555-558. |
| APA | Wu, Chunhui,Chen, Weiming,Jiang, Dehui,Jiang, Xiangrui,&Shen, Jingshan.(2015).An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride.ORGANIC PROCESS RESEARCH & DEVELOPMENT,19(4),555-558. |
| MLA | Wu, Chunhui,et al."An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride".ORGANIC PROCESS RESEARCH & DEVELOPMENT 19.4(2015):555-558. |
入库方式： OAI收割
来源：上海药物研究所
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