Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs
文献类型：期刊论文
| 作者 | Chen, Taijie4; Luo, Yu4; Hu, Youhong3 ; Yang, Bo1; Lu, Wei2
|
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013-06 |
| 卷号 | 64页码:613-620 |
| 关键词 | Pyridin-2(1H)-one Chan-Lam coupling reaction Cytotoxicity Antitumor activity Cell cycle |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2013.04.008 |
| 文献子类 | Article |
| 英文摘要 | A series of 1,6-diaryl pyridin-2(1H)-one analogs were designed and synthesized via consecutive Chan-Lam coupling and Suzuki coupling. These novel compounds were evaluated for their antiproliferative activity against two tumor cell lines (SKOV-3 and HepG2). Compounds 1b, 1c, 1e and 1f displayed comparable in vitro cytotoxicity with taxol, while their in vivo antitumor activity was less effective than taxol. In addition, cell cycle assay indicated that these 1,6-diaryl pyridin-2(1H)-one compounds induced cell cycle arrest in the G1/M phase in the HepG2 cell line. (C) 2013 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | 2-PYRIDONE DERIVATIVES ; INHIBITORS ; RECEPTOR ; AGENTS ; DISCOVERY ; DESIGN ; MOIETY ; KINASE ; POTENT ; MICE |
| 资助项目 | National Natural Science Foundation of China[81172936] ; National Natural Science Foundation of China[21102046] ; Fundamental Research Funds for the Central Universities[00000000] ; State key Laboratory of Drug Research, shanghai Institute of Materia, Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000321230300059 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277594]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Luo, Yu |
| 作者单位 | 1.Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 2.E China Normal Univ, Inst Drug Discovery & Dev, Shanghai 200062, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Taijie,Luo, Yu,Hu, Youhong,et al. Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,64:613-620. |
| APA | Chen, Taijie,Luo, Yu,Hu, Youhong,Yang, Bo,&Lu, Wei.(2013).Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,64,613-620. |
| MLA | Chen, Taijie,et al."Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 64(2013):613-620. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。