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ONE-POT SYNTHESIS OF ISOINDOLINONES VIA THREE-COMPONENT MANNICH/LACTAMIZATION CASCADE REACTION

文献类型：期刊论文

作者Zhang, Haoyi2; Leng, Yixin2; Liu, Wenjing2; Duan, Wenhu1,2
刊名SYNTHETIC COMMUNICATIONS
出版日期2012
卷号42期号:8页码:1115-1127
关键词Cascade reaction isoindolinone lactamization Mannich reaction three-component
ISSN号0039-7911
DOI10.1080/00397911.2010.535948
文献子类Article
英文摘要An efficient synthesis of 3-substituted 2,3-dihydroisoindolin-1-ones was achieved with good yields (up to 88%). The process features broad substrate scope, high efficiency, and simplicity, using an one-pot, three-component Mannich/lactamization cascade reaction in the absence or presence of p-toluenesulfonic acid.
WOS关键词HIV-1 REVERSE-TRANSCRIPTASE ; PROTEIN-PROTEIN INTERACTION ; MANNICH REACTION ; SOLVENT-FREE ; INHIBITORS ; DERIVATIVES ; RECEPTOR ; PAGOCLONE ; KINASE ; 3-ALKYL-1-ISOINDOLINONES
资助项目National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09103-065] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; Major Project of Chinese National Programs for Fundamental Research and Development[2009 CB918404] ; Ministry of Education[B07023]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000302535600004
出版者TAYLOR & FRANCIS INC
源URL[http://119.78.100.183/handle/2S10ELR8/278263]  
专题药物化学研究室
通讯作者Duan, Wenhu
作者单位1.Chinese Acad Sci, Dept Med Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Haoyi,Leng, Yixin,Liu, Wenjing,et al. ONE-POT SYNTHESIS OF ISOINDOLINONES VIA THREE-COMPONENT MANNICH/LACTAMIZATION CASCADE REACTION[J]. SYNTHETIC COMMUNICATIONS,2012,42(8):1115-1127.
APA Zhang, Haoyi,Leng, Yixin,Liu, Wenjing,&Duan, Wenhu.(2012).ONE-POT SYNTHESIS OF ISOINDOLINONES VIA THREE-COMPONENT MANNICH/LACTAMIZATION CASCADE REACTION.SYNTHETIC COMMUNICATIONS,42(8),1115-1127.
MLA Zhang, Haoyi,et al."ONE-POT SYNTHESIS OF ISOINDOLINONES VIA THREE-COMPONENT MANNICH/LACTAMIZATION CASCADE REACTION".SYNTHETIC COMMUNICATIONS 42.8(2012):1115-1127.

入库方式： OAI收割

来源：上海药物研究所

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