NOVEL AND PRACTICAL SYNTHESIS OF CANDESARTAN CILEXETIL
文献类型：期刊论文
| 作者 | Mao, Yongjun2; Xiong, Ruisheng2; Liu, Zheng1; Li, Haihong1; Shen, Jingkang2; Shen, Jingshan1,2
|
| 刊名 | HETEROCYCLES
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 81期号:6页码:1503-1508 |
| 关键词 | Atacand ARBs Synthesis Convergent Route Preparative Process |
| ISSN号 | 0385-5414 |
| DOI | 10.3987/COM-10-11944 |
| 文献子类 | Article |
| 英文摘要 | A novel and convergent synthetic route of candesartan cilexetil (API of Atacand), an effective angiotensin II receptor blocker, is described. Cleavage of the N-Boc and N-trityl protective group are implemented simultaneously and formation of the benzimidazole ring is conducted at the last step of this route, which gives candesartan cilexetil in 55% yield over six steps with 99.1% purity (HPLC). |
| WOS关键词 | II RECEPTOR ANTAGONISTS ; ESSENTIAL-HYPERTENSION ; BIOLOGICAL-ACTIVITY ; ACIDS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000279259000011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278886]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Mao, Yongjun |
| 作者单位 | 1.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Mao, Yongjun,Xiong, Ruisheng,Liu, Zheng,et al. NOVEL AND PRACTICAL SYNTHESIS OF CANDESARTAN CILEXETIL[J]. HETEROCYCLES,2010,81(6):1503-1508. |
| APA | Mao, Yongjun,Xiong, Ruisheng,Liu, Zheng,Li, Haihong,Shen, Jingkang,&Shen, Jingshan.(2010).NOVEL AND PRACTICAL SYNTHESIS OF CANDESARTAN CILEXETIL.HETEROCYCLES,81(6),1503-1508. |
| MLA | Mao, Yongjun,et al."NOVEL AND PRACTICAL SYNTHESIS OF CANDESARTAN CILEXETIL".HETEROCYCLES 81.6(2010):1503-1508. |
入库方式： OAI收割
来源：上海药物研究所
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