Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction
文献类型：期刊论文
| 作者 | Luo, Guangshun2; Zhang, Shilei2; Duan, Wenhu2,3 ; Wang, Wei1,2,3
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2009-06-17 |
| 卷号 | 50期号:24页码:2946-2948 |
| 关键词 | Cascade reactions Michael-aldol Organocatalysis Tetrahydrothiophenes |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2009.03.218 |
| 文献子类 | Article |
| 英文摘要 | A catalytic asymmetric Michael-aldol cascade process for efficient synthesis of trisubstituted tetrahydrothiophenes is reported with high enantio- and diastereo-selectivities. Notably, three consecutive stereogenic centers including one chiral quaternary carbon center are efficiently created in the 'one-pot' operation. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DIPHENYLPROLINOL SILYL ETHER ; ONE-POT SYNTHESIS ; DOMINO REACTIONS ; ALPHA,BETA-UNSATURATED ALDEHYDES ; ENANTIOENRICHED PIPERIDINES ; STEREOCONTROLLED SYNTHESIS ; CONJUGATE ADDITIONS ; ASYMMETRIC REACTION ; CARBONYL-COMPOUNDS ; 4 STEREOCENTERS |
| 资助项目 | School of Pharmacy, East China University of Science[00000000] ; National Science Foundation of China[03772648] ; National Science Foundation of China[30721005] ; Chinese National Programs for High Technology Research and Development[2006AA020602] ; Chinese National Programs for High Technology Research and Development[2007AA02Z147] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000266188300027 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279208]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Duan, Wenhu |
| 作者单位 | 1.Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA 2.E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Luo, Guangshun,Zhang, Shilei,Duan, Wenhu,et al. Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction[J]. TETRAHEDRON LETTERS,2009,50(24):2946-2948. |
| APA | Luo, Guangshun,Zhang, Shilei,Duan, Wenhu,&Wang, Wei.(2009).Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction.TETRAHEDRON LETTERS,50(24),2946-2948. |
| MLA | Luo, Guangshun,et al."Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction".TETRAHEDRON LETTERS 50.24(2009):2946-2948. |
入库方式： OAI收割
来源：上海药物研究所
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