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2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

文献类型：期刊论文

作者Duan, Hongliang1; Zheng, Jin2; Lai, Qinglin1; Liu, Zheng2; Tian, Guanghui1; Wang, Zhen1; Li, Jianfeng1; Shen, Jingshan1,2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2009-05-15
卷号19期号:10页码:2777-2779
关键词2-Phenylquinazolin-4(3H)-one PDE5 Inhibitor Selectivity versus PDE6 Sildenafil Erectile dysfunction
ISSN号0960-894X
DOI10.1016/j.bmcl.2009.03.125
文献子类Article
英文摘要In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported. (C) 2009 Elsevier Ltd. All rights reserved.
WOS关键词PHOSPHODIESTERASE-5 INHIBITORS ; ERECTILE DYSFUNCTION ; AGENTS
资助项目National 863 Program of China[2007AA02Z145] ; Shanghai Science and Technology Development Funds[08JC1422400]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000265627800037
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/279239]  
专题药物化学研究室
通讯作者Shen, Jingshan
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China
推荐引用方式
GB/T 7714		 Duan, Hongliang,Zheng, Jin,Lai, Qinglin,et al. 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(10):2777-2779.
APA Duan, Hongliang.,Zheng, Jin.,Lai, Qinglin.,Liu, Zheng.,Tian, Guanghui.,...&Shen, Jingshan.(2009).2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(10),2777-2779.
MLA Duan, Hongliang,et al."2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.10(2009):2777-2779.

入库方式： OAI收割

来源：上海药物研究所

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