中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药理学第一研究室
Anti-SARS virus action of natural marine substance: bryostatin

文献类型：期刊论文

作者Yi Yanghua2,2; Zuo Jianping3; Lin Houwen1; Li Ling2; Tang Haifeng2; Ding Jian3; Nan Fajun3
刊名Academic Journal of Second Military Medical University
出版日期2003
卷号24期号:8页码:821-822
关键词Bugula neritina bryostatin severe acute respiratory syndrome-coronavirus
ISSN号0258-879X
其他题名海洋生物活性物质总草苔虫内酯体外抗SARS相关冠状病毒的初步研究
文献子类Article
英文摘要Objective: To observe the anti-SARS virus effect of total bryostatins, a mixture of 9 bryostalins isolated from marine animal Bugula neritina. Methods: Vero-E6 cells were used as SARS virus host cells. Cytopathic effect (CPE) and cell protection rate (CPR) were used to determine the protective effects of total bryostatins against SARS virus. Bryo-statins at concentration of 4, 20 and 100 fig/ml were tested separately in 2 experiments. Results: In the prevention test, CPK were ttH.ttH.+ll CPR was 1%, 6%,39%; in the treatment test, CPE were ttt.++.fh CPR were 33%, 58%, 40%. Conclu sion; The results indicate that bryostatins with a concentration over 4 ng/ml has anti-SARS activity and protection action of SARS-infecled cell.
资助项目上海市科委新药重点基金(014319320)[00000000]
WOS研究方向General & Internal Medicine (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:1244865
源URL[http://119.78.100.183/handle/2S10ELR8/268466]  
专题药理学第一研究室
国家新药筛选中心
作者单位1.Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
2.research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.;
3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;
推荐引用方式
GB/T 7714		 Yi Yanghua,Zuo Jianping,Lin Houwen,et al. Anti-SARS virus action of natural marine substance: bryostatin[J]. Academic Journal of Second Military Medical University,2003,24(8):821-822.
APA Yi Yanghua.,Zuo Jianping.,Lin Houwen.,Li Ling.,Tang Haifeng.,...&Nan Fajun.(2003).Anti-SARS virus action of natural marine substance: bryostatin.Academic Journal of Second Military Medical University,24(8),821-822.
MLA Yi Yanghua,et al."Anti-SARS virus action of natural marine substance: bryostatin".Academic Journal of Second Military Medical University 24.8(2003):821-822.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。