Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups
文献类型：期刊论文
| 作者 | Yin, Runting1,3; Gou, Shaohua1,3; Liu, Xia1 ; Lou, Liguang2
|
| 刊名 | JOURNAL OF INORGANIC BIOCHEMISTRY
 |
| 出版日期 | 2011-08 |
| 卷号 | 105期号:8页码:1095-1101 |
| 关键词 | Platinum(II) complexes Antitumor activity Alkoxycarboxylates Toxicity Leaving groups |
| ISSN号 | 0162-0134 |
| DOI | 10.1016/j.jinorgbio.2011.05.005 |
| 文献子类 | Article |
| 英文摘要 | Five oxaliplatin-typed platinum complexes containing trans-1R, 2R-diaminocyclohexane chelating platinum cores, characteristic of linear or branched alkoxycarboxylates as leaving groups, were biologically evaluated. These compounds showed higher antitumor activity, lower toxicity in vivo than cisplatin or oxaliplatin. And the results revealed that the antitumor activity and interaction with DNA of these compounds were highly related to the nature of leaving groups. Among these complexes, 5a, cis-(trans-1R, 2R-diaminocyclohexane) bis (2-tert-butoxyacetate) platinum(II), showed the highest antitumor activity and the lowest toxicity. (C) 2011 Elsevier Inc. All rights reserved. |
| WOS关键词 | TRADITIONAL CHINESE MEDICINE ; INNOVATIVE COMBINATION ; ESCHERICHIA COLI ; CELL DIVISION ; CARBOPLATIN ; AGENTS ; CIS-DICHLORODIAMMINEPLATINUM(II) ; NEPHROTOXICITY ; CYTOTOXICITY ; INHIBITION |
| 资助项目 | National Natural Science Foundation of China[20971022] ; National Natural Science Foundation of China[20471027] ; Six Top Talents Funding of Jiangsu Province[2008046] ; National Science and Technology Major Foundation of China[2010ZX09401-401] ; Southeast University[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000292851900013 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278463]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Gou, Shaohua |
| 作者单位 | 1.Southeast Univ, Sch Chem & Chem Engn, Pharmaceut Res Ctr, Nanjing 211189, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yin, Runting,Gou, Shaohua,Liu, Xia,et al. Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2011,105(8):1095-1101. |
| APA | Yin, Runting,Gou, Shaohua,Liu, Xia,&Lou, Liguang.(2011).Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups.JOURNAL OF INORGANIC BIOCHEMISTRY,105(8),1095-1101. |
| MLA | Yin, Runting,et al."Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups".JOURNAL OF INORGANIC BIOCHEMISTRY 105.8(2011):1095-1101. |
入库方式： OAI收割
来源：上海药物研究所
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