Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR
文献类型：期刊论文
| 作者 | Chen, Hao1,5; Yi, Chengqi2,3; Zhang, Jin1,5; Zhang, Wenru4; Ge, Zhiyun1,5; Yang, Cai-Guang4 ; He, Chuan2,3
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| 刊名 | EMBO REPORTS
 |
| 出版日期 | 2010-09 |
| 卷号 | 11期号:9页码:685-690 |
| 关键词 | antibiotic resistance regulation oxidative stress Pseudomonas aeruginosa redox sensing thiol oxidation |
| ISSN号 | 1469-221X |
| DOI | 10.1038/embor.2010.96 |
| 文献子类 | Article |
| 英文摘要 | MexR functions as the primary regulator of the mexAB-oprM multidrug efflux expression in Pseudomonas aeruginosa. It has been shown that MexR senses oxidative stress by interprotomer disulphide bond formation between redox-active cysteines. This oxidation induces MexR to dissociate from the promoter DNA, thus activating the transcriptional expression of efflux pump genes. In this study, we present the crystal structure of MexR in its oxidized form at a resolution of 2.1 angstrom. This crystal structure reveals the mechanism by which oxidative signal allosterically derepresses the MexR-controlled transcription activation. |
| WOS关键词 | MULTIDRUG EFFLUX OPERON ; PSEUDOMONAS-AERUGINOSA ; CRYSTAL-STRUCTURE ; REPRESSOR ; PUMPS |
| 资助项目 | National Institutes of Health (NIAID)[R01 AI074658] ; National Natural Science Foundation of China (NSFC)[20721002] ; Chinese Academy of Sciences[00000000] ; NSFC[90913010] ; Key Project of Chinese National Programs for Fundamental Research and Development[2009CB918502] ; National Science and Technology Major Project[2009ZX09301-001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000281467200012 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278785]  |
| 专题 | 药理学第三研究室 药物靶标结构与功能中心 |
| 通讯作者 | Chen, Hao |
| 作者单位 | 1.Nanjing Univ, State Key Lab Coordinat Chem, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China; 2.Univ Chicago, Dept Chem, Chicago, IL 60637 USA; 3.Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Nanjing Univ, Inst Coordinat Chem, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Hao,Yi, Chengqi,Zhang, Jin,et al. Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR[J]. EMBO REPORTS,2010,11(9):685-690. |
| APA | Chen, Hao.,Yi, Chengqi.,Zhang, Jin.,Zhang, Wenru.,Ge, Zhiyun.,...&He, Chuan.(2010).Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR.EMBO REPORTS,11(9),685-690. |
| MLA | Chen, Hao,et al."Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR".EMBO REPORTS 11.9(2010):685-690. |
入库方式： OAI收割
来源：上海药物研究所
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