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Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin

文献类型：期刊论文

作者Li, Mingzong2; Tang, Weidong1; Zeng, Fuxing2; Lou, Liguang1; You, Tianpa2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2008-12-15
卷号18期号:24页码:6441-6443
关键词Camptothecin Camptothecin derivatives Semi-synthesis Antitumor activity Topoisomerase I
ISSN号0960-894X
DOI10.1016/j.bmcl.2008.10.074
文献子类Article
英文摘要A series of E-ring gamma-lactone camptothecin derivatives were synthesized by semi-synthesis via a three-step domino reaction. Their biological activity was evaluated on two types of human tumor cell lines A549 and HT-29 with sulforhodamine-B (SRB) method. The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity relationship (SAR) of these analogs was studied and discussed. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
WOS关键词WATER-SOLUBLE DERIVATIVES ; PLANT ANTITUMOR AGENTS ; TOPOISOMERASE-I ; 20(S)-CAMPTOTHECIN DERIVATIVES ; ALKALOID CAMPTOTHECIN ; ANTILEUKEMIC ACTIVITY ; RING ; INHIBITION
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000261141100030
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/279408]  
专题药理学第一研究室
通讯作者Lou, Liguang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Li, Mingzong,Tang, Weidong,Zeng, Fuxing,et al. Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(24):6441-6443.
APA Li, Mingzong,Tang, Weidong,Zeng, Fuxing,Lou, Liguang,&You, Tianpa.(2008).Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(24),6441-6443.
MLA Li, Mingzong,et al."Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.24(2008):6441-6443.

入库方式： OAI收割

来源：上海药物研究所

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