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NEW SYNTHESIS OF N-(4-CHLORO-3-CYANO-7-ETHOXYQUINOLIN-6-YL)ACETAMIDE

文献类型：期刊论文

作者Mao, Yongjun1; He, Yang1; Zhu, Fuqiang2; Chen, Weiming2; Shen, Jingshan1; Li, Jianfeng1
刊名HETEROCYCLES
出版日期2014-05-01
卷号89期号:5页码:1203-1209
ISSN号0385-5414
DOI10.3987/COM-13-12830
文献子类Article
英文摘要New synthetic route of N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide (1) is described on a hectogram scale. The key steps include the intramolecular cyclization of 3-amino-2-(2-chlorobenzoyl)acrylonitrile 22 to give the 3-cyano-4-quinolone 7, which was chlorinated by POCl3 to give the final product 1 in 36.9% yield over 9 steps and 98.9% purity (HPLC). Purification methods of 7 and 1 were also given.
WOS关键词INHIBITORY-ACTIVITY ; KINASE-ACTIVITY ; OPTIMIZATION ; DERIVATIVES ; 8-POSITION ; DISCOVERY ; QUINOLONE ; SUBSTRATE ; ANALOGS ; SERIES
资助项目National Science and Technology[2012ZX09301001-001] ; Science and Technology of Shanghai[10431902800]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000336872600006
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/277089]  
专题科研与新药推进处
通讯作者Mao, Yongjun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Yongjun,He, Yang,Zhu, Fuqiang,et al. NEW SYNTHESIS OF N-(4-CHLORO-3-CYANO-7-ETHOXYQUINOLIN-6-YL)ACETAMIDE[J]. HETEROCYCLES,2014,89(5):1203-1209.
APA Mao, Yongjun,He, Yang,Zhu, Fuqiang,Chen, Weiming,Shen, Jingshan,&Li, Jianfeng.(2014).NEW SYNTHESIS OF N-(4-CHLORO-3-CYANO-7-ETHOXYQUINOLIN-6-YL)ACETAMIDE.HETEROCYCLES,89(5),1203-1209.
MLA Mao, Yongjun,et al."NEW SYNTHESIS OF N-(4-CHLORO-3-CYANO-7-ETHOXYQUINOLIN-6-YL)ACETAMIDE".HETEROCYCLES 89.5(2014):1203-1209.

入库方式： OAI收割

来源：上海药物研究所

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