Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade
文献类型：期刊论文
| 作者 | Song, Hongshuo1; Ou, Weidong1; Feng, Yi1; Zhang, Junli1; Li, Fan1; Hu, Jing1; Peng, Hong1; Xing, Hui1; Ma, Liying1; Tan, Qiuxiang2 |
| 刊名 | Proceedings of the National Academy of Sciences of the United States of America
 |
| 出版日期 | 2018-12-17 |
| ISSN号 | 1091-6490 |
| DOI | 10.1073/pnas.1814714116 |
| 文献子类 | Article |
| 英文摘要 | HIV-1 evolved into various genetic subtypes and circulating recombinant forms (CRFs) in the global epidemic. The same subtype or CRF is usually considered to have similar phenotype. Being one of the world's major CRFs, CRF01_AE infection was reported to associate with higher prevalence of CXCR4 (X4) viruses and faster CD4 decline. However, the underlying mechanisms remain unclear. We identified eight phylogenetic clusters of CRF01_AE in China and hypothesized that they may have different phenotypes. In the National HIV Molecular Epidemiology Survey, we discovered that people infected by CRF01_AE cluster 4 had significantly lower CD4 counts (391 vs. 470, < 0.0001) and higher prevalence of X4-using viruses (17.1% vs. 4.4%, < 0.0001) compared with those infected by cluster 5. In an MSM cohort, X4-using viruses were only isolated from seroconvertors in cluster 4, which was associated with low a CD4 count within the first year of infection (141 vs. 440, = 0.003). Using a coreceptor binding model, we identified unique V3 signatures in cluster 4 that favor CXCR4 use. We demonstrate that the HIV-1 phenotype and pathogenicity can be determined at the phylogenetic cluster level in the same subtype. Since its initial spread to humans from chimpanzees, estimated to be the first half of the 20th century, HIV-1 continues to undergo rapid evolution in larger and more diverse populations. The divergent phenotype evolution of two major CRF01_AE clusters highlights the importance of monitoring the genetic evolution and phenotypic shift of HIV-1 to provide early warning of the appearance of more pathogenic strains. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266831]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Shao, Yiming |
| 作者单位 | 1.State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 102206 Beijing, China; 2.CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203 Shanghai, China; 3.Chaoyang Center for Disease Control and Prevention, 100021 Beijing, China |
| 推荐引用方式 GB/T 7714 | Song, Hongshuo,Ou, Weidong,Feng, Yi,et al. Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade[J]. Proceedings of the National Academy of Sciences of the United States of America,2018. |
| APA | Song, Hongshuo.,Ou, Weidong.,Feng, Yi.,Zhang, Junli.,Li, Fan.,...&Shao, Yiming.(2018).Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade.Proceedings of the National Academy of Sciences of the United States of America. |
| MLA | Song, Hongshuo,et al."Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade".Proceedings of the National Academy of Sciences of the United States of America (2018). |
入库方式： OAI收割
来源：上海药物研究所
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