The application of the bioisosterism in lead optimization
文献类型：期刊论文
| 作者 | Cui Yongmei; Nan Fajun
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2006 |
| 卷号 | 18期号:2页码:161-167 |
| 关键词 | bioisosterism lead compound structure optimization |
| ISSN号 | 1004-0374 |
| 其他题名 | 生物电子等排原理在药物先导化合物优化中的应用 |
| 文献子类 | Review |
| 英文摘要 | The rational optimization of lead compounds into drug candidates is very important in the process of new drug development. Because a lead compound with a desired pharmacological activity may have associated with its drawbacks of pharmacology to promise the clinical usage, it is necessary to chemically modify the compounds to exclude such drawbacks by various approaches. The bioisosteric replacement represents a successful one. We herein review the principle of bioisosterism and some examples. |
| 资助项目 | 上海市科委创新群体项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2461228 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268250]  |
| 专题 | 国家新药筛选中心 |
| 作者单位 | National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Cui Yongmei,Nan Fajun. The application of the bioisosterism in lead optimization[J]. Chinese Bulletin of Life Sciences,2006,18(2):161-167. |
| APA | Cui Yongmei,&Nan Fajun.(2006).The application of the bioisosterism in lead optimization.Chinese Bulletin of Life Sciences,18(2),161-167. |
| MLA | Cui Yongmei,et al."The application of the bioisosterism in lead optimization".Chinese Bulletin of Life Sciences 18.2(2006):161-167. |
入库方式： OAI收割
来源：上海药物研究所
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