Advanced in free fatty acid receptor GPR84 and its modulators
文献类型：期刊论文
| 作者 | Liu Yang2; Chen Linhai1 ; Lv Wei2; Nan Fajun1
|
| 刊名 | Chemistry of Life
 |
| 出版日期 | 2016 |
| 卷号 | 36期号:4页码:548-555 |
| 关键词 | GPCR medium chain fatty acid (MCFA) GPR84 inflammation modulator |
| ISSN号 | 1000-1336 |
| 其他题名 | 脂肪酸受体GPR84及其调节剂的研究进展 |
| 文献子类 | Review |
| 英文摘要 | GPR84 belongs to free fatty acid receptors (FFAR) and it is mainly activated by MCFA (C9-14). GPR84 is highly expressed in human bone marrow, and to a lesser extent, in the peripheral leukocytes and lungs. In physiological conditions, the expression of GPR84 is low, but it can increase remarkably in monocytes/ macrophages upon activation by lipopolysaccharide. Several recent studies also showed that GPR84 plays a significant role in inflammation, and GPR84 modulators therefore have potential use in regulating inflammation. In this review, we summarize the recent advances on GPR84 and its modulators. |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5785557 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269241]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Nan Fajun |
| 作者单位 | 1.Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai 201203, China. 2.School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.; |
| 推荐引用方式 GB/T 7714 | Liu Yang,Chen Linhai,Lv Wei,et al. Advanced in free fatty acid receptor GPR84 and its modulators[J]. Chemistry of Life,2016,36(4):548-555. |
| APA | Liu Yang,Chen Linhai,Lv Wei,&Nan Fajun.(2016).Advanced in free fatty acid receptor GPR84 and its modulators.Chemistry of Life,36(4),548-555. |
| MLA | Liu Yang,et al."Advanced in free fatty acid receptor GPR84 and its modulators".Chemistry of Life 36.4(2016):548-555. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。