Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms
文献类型：期刊论文
| 作者 | Li, Jing2 ; Tian, Yanxin2; Guo, Shimeng2; Gu, Haifeng2; Yuan, Qianting2; Xie, Xin1,2
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| 刊名 | PLOS ONE
 |
| 出版日期 | 2018-01-19 |
| 卷号 | 13期号:1 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0191469 |
| 文献子类 | Article |
| 英文摘要 | Benign prostatic hyperplasia (BPH) is an age-related disease, affecting a majority of elderly men worldwide. Medical management of BPH is an alternative to surgical treatment of this disease. Currently, alpha(1)-adrenergic receptor (alpha(1)-AR) antagonists are among the first line drugs to treat BPH by reducing the tension of urinary track and thus the obstructive symptoms in voiding. In drug development, old male dogs with spontaneous BPH are considered the golden standard of the animal models. However, old dogs (>6 years) are expensive and not all old dogs develop BPH. So it is necessary to develop more accessible animal models for drug efficacy evaluation. Here we describe the development of testosterone-induced BPH models in both rats and young adult dogs and their applications in the in vivo evaluation of alpha 1-AR antagonist. The BPH rats and dogs induced by chronic testosterone treatment have significantly increased micturition frequency and reduced mean voided volume, very similar to the clinical symptoms of BPH patients. Silodosin, an alpha 1-AR antagonist, significantly reduces the urinary frequency and increases the voided volume in BPH model animals in a dose-dependent manner. The results demonstrate that testosterone-induced BPH rat and dog models might provide a more efficient way to evaluate micturition behavior in anti-BPH drug studies. |
| WOS关键词 | THERAPEUTIC AGENTS ; OUTLET OBSTRUCTION ; BLADDER ; ANTAGONISTS ; HORMONE ; GROWTH ; PATHOPHYSIOLOGY ; MICTURITION ; PREVALENCE ; PRESSURE |
| 资助项目 | National Natural Sciences Foundation of China[81425024] ; National Natural Sciences Foundation of China[81573442] ; Personalized Medicines Molecular Signature-based Drug Discovery and Development[00000000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040212] ; Shanghai Commission of Science and Technology[16431901500] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2017ZX09101004-012-008] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIM M0120151007] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000422911300094 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272280]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Li, Jing; Xie, Xin |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Natl Ctr Drug Screening, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Jing,Tian, Yanxin,Guo, Shimeng,et al. Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms[J]. PLOS ONE,2018,13(1). |
| APA | Li, Jing,Tian, Yanxin,Guo, Shimeng,Gu, Haifeng,Yuan, Qianting,&Xie, Xin.(2018).Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms.PLOS ONE,13(1). |
| MLA | Li, Jing,et al."Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms".PLOS ONE 13.1(2018). |
入库方式： OAI收割
来源：上海药物研究所
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