Catalyst-Controlled [3+2] and [4+2] Annulations of Oximes with Propargyl Alcohols: Divergent Access to Indenamines and Isoquinolines
文献类型：期刊论文
| 作者 | Gong, Wanchun1,2,3; Zhou, Zhi1,2; Shi, Jingjing4 ; Wu, Bo1,2; Huang, Biyun1,2; Yi, Wei1,2
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2018-01-05 |
| 卷号 | 20期号:1页码:182-185 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett7b03546 |
| 文献子类 | Article |
| 英文摘要 | Rhodium(III)- and iridium(III)-catalyzed C-H activation of oximes and coupling with propargyl alcohols is discussed. Depending on the catalyst, the reaction pathway switched between [3 + 2] and [4 + 2] annulation, thus giving divergent access to indenamines and isoquinolines in a one-pot and atom-economical manner. The hydroxyl group in the tertiary propargyl alcohol substrate was found to be crucial in controlling chemoselectivity. Five-membered rhodacycle and iridacycle intermediates have also been identified for mechanism hypotheses. |
| WOS关键词 | C-H FUNCTIONALIZATION ; BOND ACTIVATION ; N-OXIDES ; ARENES ; ALKYNES ; ISOINDOLINONES ; ALLENYLATION ; CONSTRUCTION |
| 资助项目 | NSFC[81502909] ; Guangdong Natural Science Funds for Distinguished Young Scholar[2017A030306031] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000419749700047 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272288]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Yi, Wei |
| 作者单位 | 1.Guangzhou Med Univ, Key Lab Mol Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China; 2.Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China; 3.Shanghai Pharmaceut Holding Co Ltd, Cent Res Inst, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, VARI SIMM Ctr, CAS Key Lab Receptor Res,Ctr Struct & Funct Drug, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gong, Wanchun,Zhou, Zhi,Shi, Jingjing,et al. Catalyst-Controlled [3+2] and [4+2] Annulations of Oximes with Propargyl Alcohols: Divergent Access to Indenamines and Isoquinolines[J]. ORGANIC LETTERS,2018,20(1):182-185. |
| APA | Gong, Wanchun,Zhou, Zhi,Shi, Jingjing,Wu, Bo,Huang, Biyun,&Yi, Wei.(2018).Catalyst-Controlled [3+2] and [4+2] Annulations of Oximes with Propargyl Alcohols: Divergent Access to Indenamines and Isoquinolines.ORGANIC LETTERS,20(1),182-185. |
| MLA | Gong, Wanchun,et al."Catalyst-Controlled [3+2] and [4+2] Annulations of Oximes with Propargyl Alcohols: Divergent Access to Indenamines and Isoquinolines".ORGANIC LETTERS 20.1(2018):182-185. |
入库方式： OAI收割
来源：上海药物研究所
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